| Circadian food anticipation persists in capsaicin deafferented rats. | |
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MedLine Citation:
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PMID: 9783233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The feeding-entrained circadian oscillator (FEO) organizes locomotor activity and other variables to anticipate daily timed meals. Whether the biological substrate for the FEO is in the central nervous system or in the periphery, there must be communication between the gut and the brain to result in a behavioral output. To investigate potential neural routes of communication, rats with suprachiasmatic lesions were given systemic capsaicin (total dose: 100 mg/kg, i.p.) to produce visceral deafferentation. Deafferentation was confirmed using the phenyl-p-benzoquinone stretch test and the corneal irritation test. A 3-h meal was made available at the same time each day while wheel running was recorded for several weeks. Results indicated that rats with capsaicin lesions were somewhat more active overall and during nonanticipation times, but the onset time and the amount of anticipatory wheel running did not differ from vehicle-treated controls. In addition, reentrainment following a phase delay of mealtime and the persistence of anticipatory activity during food deprivation were similar between the groups. Since capsaicin deafferentation and subdiaphragmatic vagotomy do not prevent food-anticipatory activity, it is likely that communication between the gut and the brain is accomplished via a humoral route. |
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Authors:
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A J Davidson; F K Stephan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biological rhythms Volume: 13 ISSN: 0748-7304 ISO Abbreviation: J. Biol. Rhythms Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-12-18 Completed Date: 1998-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 422-9 Citation Subset: IM |
Affiliation:
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Department of Psychology, Florida State University, Tallahassee 32306-1270, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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drug effects Animals Capsaicin / pharmacology* Circadian Rhythm / physiology* Denervation Feeding Behavior / physiology* Male Motor Activity / physiology Rats Rats, Sprague-Dawley Suprachiasmatic Nucleus / physiology Viscera / drug effects*, innervation* |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK 50224/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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