Document Detail


Circadian food anticipation persists in capsaicin deafferented rats.
MedLine Citation:
PMID:  9783233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The feeding-entrained circadian oscillator (FEO) organizes locomotor activity and other variables to anticipate daily timed meals. Whether the biological substrate for the FEO is in the central nervous system or in the periphery, there must be communication between the gut and the brain to result in a behavioral output. To investigate potential neural routes of communication, rats with suprachiasmatic lesions were given systemic capsaicin (total dose: 100 mg/kg, i.p.) to produce visceral deafferentation. Deafferentation was confirmed using the phenyl-p-benzoquinone stretch test and the corneal irritation test. A 3-h meal was made available at the same time each day while wheel running was recorded for several weeks. Results indicated that rats with capsaicin lesions were somewhat more active overall and during nonanticipation times, but the onset time and the amount of anticipatory wheel running did not differ from vehicle-treated controls. In addition, reentrainment following a phase delay of mealtime and the persistence of anticipatory activity during food deprivation were similar between the groups. Since capsaicin deafferentation and subdiaphragmatic vagotomy do not prevent food-anticipatory activity, it is likely that communication between the gut and the brain is accomplished via a humoral route.
Authors:
A J Davidson; F K Stephan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  13     ISSN:  0748-7304     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  422-9     Citation Subset:  IM    
Affiliation:
Department of Psychology, Florida State University, Tallahassee 32306-1270, USA.
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / drug effects
Animals
Capsaicin / pharmacology*
Circadian Rhythm / physiology*
Denervation
Feeding Behavior / physiology*
Male
Motor Activity / physiology
Rats
Rats, Sprague-Dawley
Suprachiasmatic Nucleus / physiology
Viscera / drug effects*,  innervation*
Grant Support
ID/Acronym/Agency:
R01-DK 50224/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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