Document Detail

Circadian expression of transcription factor Fra-2 in the rat pineal gland.
MedLine Citation:
PMID:  7592994     Owner:  NLM     Status:  MEDLINE    
Physiological changes in Fos-like immunoreactivity in the rat pineal gland are shown here to be due primarily to changes in a 42/46-kDa Fos-related antigen (Fra). Studies are presented that indicate this 42/46-kDa Fra is Fra-2, a poorly understood member of the Fos family of transcription factors. Both Fra-2 mRNA and protein are absent during the day and increase robustly at night on a circadian basis; organ culture studies indicate that regulation is mediated by an adrenergic-->cyclic AMP mechanism. AP-1 binding activity changes in parallel to changes in the level of Fra-2 protein.
R Baler; D C Klein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  270     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-26     Completed Date:  1995-12-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27319-25     Citation Subset:  IM    
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Amino Acid Sequence
Arylamine N-Acetyltransferase / metabolism
Base Sequence
Cell Line
Circadian Rhythm / genetics,  physiology*
Cyclic AMP / metabolism
DNA Primers / genetics
DNA-Binding Proteins / genetics,  metabolism*
Fos-Related Antigen-2
Gene Expression
Molecular Sequence Data
Oligonucleotide Probes / genetics
Pineal Gland / metabolism*
Polymerase Chain Reaction
RNA, Messenger / genetics,  metabolism
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / metabolism
Sequence Homology, Amino Acid
Transcription Factor AP-1 / metabolism
Transcription Factors / genetics,  metabolism*
Reg. No./Substance:
0/DNA Primers; 0/DNA-Binding Proteins; 0/FOSL2 protein, human; 0/Fos-Related Antigen-2; 0/Fosl2 protein, rat; 0/Oligonucleotide Probes; 0/RNA, Messenger; 0/Receptors, Adrenergic, beta; 0/Transcription Factor AP-1; 0/Transcription Factors; 60-92-4/Cyclic AMP; EC N-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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