Document Detail

Circadian expression of clock genes in the rat eye and brain.
MedLine Citation:
PMID:  17202856     Owner:  NLM     Status:  MEDLINE    
The light sensing system in the eye directly affects the circadian oscillator in the mammalian suprachiasmatic nucleus (SCN). To investigate this relationship in the rat, we examined the circadian expression of clock genes in the SCN and eye tissue during a 24 h day/night cycle. In the SCN, rPer1 and rPer2 mRNAs were expressed in a clear circadian rhythm like rCry1 and rCry2 mRNAs, whereas the level of BMAL1 and CLOCK mRNAs decreased during the day and increased during the night with a relatively low amplitude. It seems that the clock genes of the SCN may function in response to a master clock oscillation in the rat. In the eye, the rCry1 and rCry2 were expressed in a circadian rhythm with an increase during subjective day and a decrease during subjective night. However, the expression of Opn4 mRNA did not exhibit a clear circadian pattern, although its expression was higher in daytime than at night. This suggests that cryptochromes located in the eye, rather than melanopsin, are the major photoreceptive system for synchronizing the circadian rhythm of the SCN in the rat.
Kyungbae Park; Hae Mook Kang
Related Documents :
11982626 - Gradients in the circadian expression of per1 and per2 genes in the rat suprachiasmatic...
8980526 - Circadian expression of the carbonic anhydrase gene, cah1, in chlamydomonas reinhardtii.
24186846 - N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-fos protein and mrna e...
23034386 - K+-cl- cotransporter-2 kcc2 in chicken cardiomyocytes.
8342646 - Fluid shear stress stimulates platelet-derived growth factor expression in endothelial ...
2174106 - Interleukin-1 synergy with phosphoinositide pathway agonists for induction of interleuk...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecules and cells     Volume:  22     ISSN:  1016-8478     ISO Abbreviation:  Mol. Cells     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-04-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  IM    
Department of Genetic Engineering, Cheongju University, Cheongju 360-764, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Clocks / genetics*
Circadian Rhythm / genetics*
Eye / metabolism*
Flavoproteins / genetics
Gene Expression Regulation
RNA, Messenger
Rats, Sprague-Dawley
Rod Opsins / genetics
Suprachiasmatic Nucleus / metabolism*
Reg. No./Substance:
0/Cryptochromes; 0/Flavoproteins; 0/RNA, Messenger; 0/Rod Opsins; 0/melanopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential effects of two period genes on the physiology and proteomic profiles of mouse anterior ...
Next Document:  Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells.