Document Detail

Circadian disruption leads to loss of homeostasis and disease.
MedLine Citation:
PMID:  23471148     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The relevance of a synchronized temporal order for adaptation and homeostasis is discussed in this review. We present evidence suggesting that an altered temporal order between the biological clock and external temporal signals leads to disease. Evidence mainly based on a rodent model of "night work" using forced activity during the sleep phase suggests that altered activity and feeding schedules, out of phase from the light/dark cycle, may be the main cause for the loss of circadian synchrony and disease. It is proposed that by avoiding food intake during sleep hours the circadian misalignment and adverse consequences can be prevented. This review does not attempt to present a thorough revision of the literature, but instead it aims to highlight the association between circadian disruption and disease with special emphasis on the contribution of feeding schedules in circadian synchrony.
Carolina Escobar; Roberto Salgado-Delgado; Eduardo Gonzalez-Guerra; Araceli Tapia Osorio; Manuel Angeles-Castellanos; Ruud M Buijs
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Publication Detail:
Type:  Journal Article     Date:  2012-01-24
Journal Detail:
Title:  Sleep disorders     Volume:  2011     ISSN:  2090-3545     ISO Abbreviation:  Sleep Disord     Publication Date:  2011  
Date Detail:
Created Date:  2013-03-08     Completed Date:  2013-03-11     Revised Date:  2013-03-12    
Medline Journal Info:
Nlm Unique ID:  101600304     Medline TA:  Sleep Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  964510     Citation Subset:  -    
Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, 04360 Mexico City, DF, Mexico.
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