Document Detail

Circadian control of tissue homeostasis and adult stem cells.
MedLine Citation:
PMID:  25016176     Owner:  NLM     Status:  Publisher    
The circadian timekeeping mechanism adapts physiology to the 24-hour light/dark cycle. However, how the outputs of the circadian clock in different peripheral tissues communicate and synchronize each other is still not fully understood. The circadian clock has been implicated in the regulation of numerous processes, including metabolism, the cell cycle, cell differentiation, immune responses, redox homeostasis, and tissue repair. Accordingly, perturbation of the machinery that generates circadian rhythms is associated with metabolic disorders, premature ageing, and various diseases including cancer. Importantly, it is now possible to target circadian rhythms through systemic or local delivery of time cues or compounds. Here, we summarize recent findings in peripheral tissues that link the circadian clock machinery to tissue-specific functions and diseases.
Peggy Janich; Qing-Jun Meng; Salvador Aznar Benitah
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Publication Detail:
Type:  REVIEW     Date:  2014-7-9
Journal Detail:
Title:  Current opinion in cell biology     Volume:  31C     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  8-15     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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