Document Detail


Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina.
MedLine Citation:
PMID:  15845344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circadian clocks are self-sustaining genetically based molecular machines that impose approximately 24h rhythmicity on physiology and behavior that synchronize these functions with the solar day-night cycle. Circadian clocks in the vertebrate retina optimize retinal function by driving rhythms in gene expression, photoreceptor outer segment membrane turnover, and visual sensitivity. This review focuses on recent progress in understanding how clocks and light control arylalkylamine N-acetyltransferase (AANAT), which is thought to drive the daily rhythm in melatonin production in those retinas that synthesize the neurohormone; AANAT is also thought to detoxify arylalkylamines through N-acetylation. The review will cover evidence that cAMP is a major output of the circadian clock in photoreceptor cells; and recent advances indicating that clocks and clock networks occur in multiple cell types of the retina.
Authors:
P Michael Iuvone; Gianluca Tosini; Nikita Pozdeyev; Rashidul Haque; David C Klein; Shyam S Chaurasia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Progress in retinal and eye research     Volume:  24     ISSN:  1350-9462     ISO Abbreviation:  Prog Retin Eye Res     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-31     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9431859     Medline TA:  Prog Retin Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-56     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, rm. 5107, Atlanta, GA 30322, USA. miuvone@pharm.emory.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Arylamine N-Acetyltransferase / metabolism*
Biological Clocks / physiology*
Circadian Rhythm / physiology*
Cyclic AMP / metabolism
Humans
Light
Melatonin / biosynthesis*
Retina / metabolism*
Grant Support
ID/Acronym/Agency:
EY04864/EY/NEI NIH HHS; EY14764/EY/NEI NIH HHS; MH062144/MH/NIMH NIH HHS; NS043459/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
60-92-4/Cyclic AMP; 73-31-4/Melatonin; EC 2.3.1.5/Arylamine N-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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