Document Detail

Circadian and circannual variations of cell cycle distribution in the mouse bone marrow.
MedLine Citation:
PMID:  3370713     Owner:  NLM     Status:  MEDLINE    
The cell cycle distribution of bone marrow cells from the femurs of female C3H mice has been investigated by flow cytometry according to the time of the day and month of the year. Both circadian and seasonal variations were found for the different cell cycle phases as well as the total cell numbers per femur. Both the mesor, the acrophase and the amplitude of the S, G2 and (G1 + G0) phases varied significantly in some months, while in other months only insignificant rhythms were found. The relative cell cycle distribution only partly reflected variations in the total numbers of proliferating cells, since the total cell number per femur was also variable. The total numbers of cells in DNA synthesis seem to be higher in the first part of the year, indicating increased cell proliferation during winter and spring. In this period the acrophases of DNA synthesis and G2 were in the morning, while the second half of the year showed the peak later in the day. In general, hemopoietic cell proliferation seems to constitute a labile equilibrium with rapidly changing activities.
O D Laerum; O Sletvold; T Riise
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chronobiology international     Volume:  5     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-24     Completed Date:  1988-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19-35     Citation Subset:  IM    
Gade Institute, Department of Pathology, University of Bergen, Norway.
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MeSH Terms
Cell Cycle
Cell Separation
Circadian Rhythm*
DNA Replication
Flow Cytometry
Hematopoietic Stem Cells / physiology*
Mice, Inbred C3H

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