Document Detail

Circadian blood pressure variation in transgenic hypertensive rats.
MedLine Citation:
PMID:  8319999     Owner:  NLM     Status:  MEDLINE    
Automatic, around-the-clock blood pressure measurements have increased our understanding of hypertension in humans. Patients with essential hypertension display patterns similar to those observed in normotensive subjects, whereas those with secondary hypertension frequently show abnormal circadian rhythms characterized by a failure to reduce blood pressure at night. We have modeled this situation in rats. Normotensive Wistar-Kyoto and Sprague-Dawley rats, spontaneously hypertensive rats, and rats made hypertensive by transgenic implantation of the mouse salivary gland renin gene (TGR[mRen-2]27) underwent chronic implantation of a device that telemetrically monitored their blood pressures, heart rates, and motor activities. In either normotensive or hypertensive rats, motor activity peaked during the dark phase, indicating that animals from all strains were nocturnal. In both normotensive and spontaneously hypertensive rats, the 24-hour blood pressure and heart rate profiles showed peak values during the rats' active phase at night, ie, between midnight and 3 AM. In the transgenic rats, on the other hand, blood pressure values were at maximum during the day around noon, when the rats were in their resting phase. The heart rate of the transgenic rats nevertheless still peaked around midnight. These data suggest that normotensive rats and those with primary and secondary hypertension display circadian rhythms of blood pressure and heart rate analogous to those observed in normotensive and primary or secondary hypertensive humans, respectively. The TGR(mRen-2)27 strain may be a useful model with which to investigate the mechanisms responsible for alterations in circadian rhythms of blood pressure and heart rate in forms of secondary hypertension.
B Lemmer; A Mattes; M Böhm; D Ganten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  22     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Center of Pharmacology, JW Goethe-University, Frankfurt, Germany.
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MeSH Terms
Analysis of Variance
Animals, Genetically Modified
Blood Pressure / physiology*
Circadian Rhythm*
Disease Models, Animal
Heart Rate / physiology
Hypertension / physiopathology*
Infant, Newborn
Motor Activity / physiology
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Renin / physiology
Reg. No./Substance:

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