Document Detail

Circadian blood pressure variation in patients with type 2 diabetes--relationship to macro- and microvascular subclinical organ damage.
MedLine Citation:
PMID:  21546328     Owner:  NLM     Status:  MEDLINE    
AIMS: To explore the association between nocturnal blood pressure (BP) dipper status and macro- and microvascular organ damage in type 2 diabetes.
METHODS: Cross-sectional data from 663 patients with type 2 diabetes, aged 55-66 years, were analysed. Nurses measured office BP and ambulatory BP during 24h. Individuals with ≥ 10% difference in nocturnal systolic blood pressure (SBP) relative to daytime values were defined as dippers. Non-dippers were defined as <10% nocturnal decrease in SBP. Estimated glomerular filtration rate (GFR) was calculated and microalbuminuria was measured by albumin:creatinine ratio (ACR). Aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries.
RESULTS: We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p<0.001).
CONCLUSIONS: We conclude that diurnal BP variation provides further information about early macro- and microvascular subclinical organ damage that goes beyond standardized office BP measurements in patients with type 2 diabetes.
Pär E son Jennersjö; Magnus Wijkman; Ann-Britt Wiréhn; Toste Länne; Jan Engvall; Fredrik H Nystrom; Carl J Östgren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-05
Journal Detail:
Title:  Primary care diabetes     Volume:  5     ISSN:  1878-0210     ISO Abbreviation:  Prim Care Diabetes     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-08-25     Completed Date:  2012-01-03     Revised Date:  2012-10-17    
Medline Journal Info:
Nlm Unique ID:  101463825     Medline TA:  Prim Care Diabetes     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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MeSH Terms
Albuminuria / etiology,  physiopathology
Aorta / physiopathology
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Carotid Arteries / physiopathology
Circadian Rhythm*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / complications*,  physiopathology
Diabetic Angiopathies / diagnosis,  etiology*,  physiopathology
Diabetic Nephropathies / etiology,  physiopathology
Early Diagnosis
Echocardiography, Doppler
Femoral Artery / physiopathology
Glomerular Filtration Rate
Hypertension / diagnosis,  etiology*,  physiopathology
Kidney / physiopathology
Linear Models
Middle Aged
Office Visits
Predictive Value of Tests
Prospective Studies
Pulsatile Flow
Risk Assessment
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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