| Circadian blood pressure variation in patients with type 2 diabetes--relationship to macro- and microvascular subclinical organ damage. | |
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MedLine Citation:
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PMID: 21546328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To explore the association between nocturnal blood pressure (BP) dipper status and macro- and microvascular organ damage in type 2 diabetes. METHODS: Cross-sectional data from 663 patients with type 2 diabetes, aged 55-66 years, were analysed. Nurses measured office BP and ambulatory BP during 24h. Individuals with ≥ 10% difference in nocturnal systolic blood pressure (SBP) relative to daytime values were defined as dippers. Non-dippers were defined as <10% nocturnal decrease in SBP. Estimated glomerular filtration rate (GFR) was calculated and microalbuminuria was measured by albumin:creatinine ratio (ACR). Aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries. RESULTS: We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p<0.001). CONCLUSIONS: We conclude that diurnal BP variation provides further information about early macro- and microvascular subclinical organ damage that goes beyond standardized office BP measurements in patients with type 2 diabetes. |
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Authors:
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Pär E son Jennersjö; Magnus Wijkman; Ann-Britt Wiréhn; Toste Länne; Jan Engvall; Fredrik H Nystrom; Carl J Östgren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-05 |
Journal Detail:
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Title: Primary care diabetes Volume: 5 ISSN: 1878-0210 ISO Abbreviation: Prim Care Diabetes Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-08-25 Completed Date: 2012-01-03 Revised Date: 2012-10-17 |
Medline Journal Info:
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Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: England |
Other Details:
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Languages: eng Pagination: 167-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01049737 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albuminuria / etiology, physiopathology Aorta / physiopathology Blood Pressure* Blood Pressure Monitoring, Ambulatory Carotid Arteries / physiopathology Circadian Rhythm* Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications*, physiopathology Diabetic Angiopathies / diagnosis, etiology*, physiopathology Diabetic Nephropathies / etiology, physiopathology Early Diagnosis Echocardiography, Doppler Female Femoral Artery / physiopathology Glomerular Filtration Rate Humans Hypertension / diagnosis, etiology*, physiopathology Kidney / physiopathology Linear Models Male Manometry Microcirculation* Middle Aged Office Visits Predictive Value of Tests Prospective Studies Pulsatile Flow Risk Assessment Risk Factors Sweden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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