|Circadian blood pressure variation in patients with type 2 diabetes--relationship to macro- and microvascular subclinical organ damage.|
|PMID: 21546328 Owner: NLM Status: MEDLINE|
|AIMS: To explore the association between nocturnal blood pressure (BP) dipper status and macro- and microvascular organ damage in type 2 diabetes.
METHODS: Cross-sectional data from 663 patients with type 2 diabetes, aged 55-66 years, were analysed. Nurses measured office BP and ambulatory BP during 24h. Individuals with ≥ 10% difference in nocturnal systolic blood pressure (SBP) relative to daytime values were defined as dippers. Non-dippers were defined as <10% nocturnal decrease in SBP. Estimated glomerular filtration rate (GFR) was calculated and microalbuminuria was measured by albumin:creatinine ratio (ACR). Aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries.
RESULTS: We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p<0.001).
CONCLUSIONS: We conclude that diurnal BP variation provides further information about early macro- and microvascular subclinical organ damage that goes beyond standardized office BP measurements in patients with type 2 diabetes.
|Pär E son Jennersjö; Magnus Wijkman; Ann-Britt Wiréhn; Toste Länne; Jan Engvall; Fredrik H Nystrom; Carl J Östgren|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-05|
|Title: Primary care diabetes Volume: 5 ISSN: 1878-0210 ISO Abbreviation: Prim Care Diabetes Publication Date: 2011 Oct|
|Created Date: 2011-08-25 Completed Date: 2012-01-03 Revised Date: 2012-10-17|
Medline Journal Info:
|Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: England|
|Languages: eng Pagination: 167-73 Citation Subset: IM|
|Copyright © 2011 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.|
|Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.|
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Albuminuria / etiology, physiopathology
Aorta / physiopathology
Blood Pressure Monitoring, Ambulatory
Carotid Arteries / physiopathology
Diabetes Mellitus, Type 2 / complications*, physiopathology
Diabetic Angiopathies / diagnosis, etiology*, physiopathology
Diabetic Nephropathies / etiology, physiopathology
Femoral Artery / physiopathology
Glomerular Filtration Rate
Hypertension / diagnosis, etiology*, physiopathology
Kidney / physiopathology
Predictive Value of Tests
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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