| Circadian blood pressure variation in patients with type 2 diabetes - relationship to macro- and microvascular subclinical organ damage. | |
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MedLine Citation:
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PMID: 21546328 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: To explore the association between nocturnal blood pressure (BP) dipper status and macro- and microvascular organ damage in type 2 diabetes. METHODS: Cross-sectional data from 663 patients with type 2 diabetes, aged 55-66 years, were analysed. Nurses measured office BP and ambulatory BP during 24h. Individuals with ≥10% difference in nocturnal systolic blood pressure (SBP) relative to daytime values were defined as dippers. Non-dippers were defined as <10% nocturnal decrease in SBP. Estimated glomerular filtration rate (GFR) was calculated and microalbuminuria was measured by albumin:creatinine ratio (ACR). Aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries. RESULTS: We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p=0.008), lower ACR (p=0.001) and NT-proBNP (p=0.001) and increased GFR (p<0.001). CONCLUSIONS: We conclude that diurnal BP variation provides further information about early macro- and microvascular subclinical organ damage that goes beyond standardized office BP measurements in patients with type 2 diabetes. |
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Authors:
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Pär E Son Jennersjö; Magnus Wijkman; Ann-Britt Wiréhn; Toste Länne; Jan Engvall; Fredrik H Nystrom; Carl J Ostgren |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
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Title: Primary care diabetes Volume: - ISSN: 1751-9918 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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