Document Detail

Circadian blood pressure in patients in a persistent vegetative state.
MedLine Citation:
PMID:  8928913     Owner:  NLM     Status:  MEDLINE    
We examined circadian variations in blood pressure, pulse rate, and other physiological variables, including hormone levels, in 16 patients in a persistent vegetative state (mean age -/+ SE; 66.1 -+/ 3.9 yr). Cerebrovascular accident was responsible for brain damage in 12 (75%) of the 16 patients. Blood pressure was measured for 24 h with an ambulatory blood pressure monitoring device. We monitored the temperature of the urinary bladder and measured urinary excretion of epinephrine, norepinephrine, 17-hydroxycorticosteroids, water, and sodium. When data were analyzed by analysis of variance, significant circadian changes were observed in body temperature and urinary excretion of hormones and sodium, but not in blood pressure or pulse rate. Individual analysis of rhythmicity using the cosinor method detected small but significant circadian variations in blood pressure and pulse rate in five of six patients who showed a simple organized response to noxious external stimuli. The disappearance of variation in blood pressure in patients in a vegetative state appeared to be related, in part, to the lack of response to external stimuli. Our findings suggest that the circadian variation in blood pressure may largely depend on external environmental factors.
Y Fukudome; I Abe; Y Saku; K Matsumura; S Sadoshima; H Utunomiya; M Fujishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  270     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1109-14     Citation Subset:  IM    
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka Japan.
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Body Temperature
Brain / pathology,  physiopathology
Circadian Rhythm*
Electrolytes / urine
Hormones / urine
Middle Aged
Persistent Vegetative State / pathology,  physiopathology*
Reg. No./Substance:
0/Electrolytes; 0/Hormones

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