Document Detail

Circadian biology: clocks within clocks.
MedLine Citation:
PMID:  15964264     Owner:  NLM     Status:  MEDLINE    
A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures. Rather little is known of the neurotransmitters involved, or their regulation.
Hugh D Piggins; Andrew Loudon
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Current biology : CB     Volume:  15     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-20     Completed Date:  2005-10-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R455-7     Citation Subset:  IM    
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
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MeSH Terms
Cell Cycle Proteins
Circadian Rhythm / genetics*
DNA-Binding Proteins / genetics
Gene Expression Regulation
Nuclear Proteins / genetics
Period Circadian Proteins
Receptors, Cytoplasmic and Nuclear / genetics
Suprachiasmatic Nucleus / physiology*
Transcription Factors / genetics
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DBP protein, rat; 0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Per2 protein, rat; 0/Period Circadian Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 56-12-2/gamma-Aminobutyric Acid
Comment On:
Curr Biol. 2005 Jun 21;15(12):R449-50   [PMID:  15964261 ]

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