| Circadian behavior of P-wave duration, P-wave area, and PR interval in healthy subjects. | |
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MedLine Citation:
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PMID: 11333165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prolongation of P-wave duration has long been shown to indicate the presence of high risk for atrial fibrillation. The circadian variation of P-wave characteristics and their dynamic adaptation to heart rate changes was not tested before. METHODS: To evaluate the diurnal pattern of P-wave duration, P area, and PR interval and of their linearly fitted relation with RR interval, 50 healthy volunteers (25 men, mean age 34 +/- 10 years) underwent 24-hour ambulatory electrocardiographic (ECG) recording with digital 12-lead Holter recorders. The median P-wave duration, P area, and PR interval were calculated from the average 12-lead ECG constructed from each 10-second ECG recording. Single harmonic regression analysis was performed to reveal the presence of circadian variation in the aforementioned ECG parameters. RESULTS: The P area (P < 0.0001, R(2) = 0.78), the PR interval (P < 0.0001, R(2) = 0.92), the P area / RR slope (P < 0.0001, R(2) = 0.55), and the PR/RR slope (P < 0.0001, R(2) = 0.42) showed a highly significant circadian variation while the periodic nature of P-wave duration (P = 0.016, R(2) = 0.32) and of the P duration / RR slope (P = 0.011, R(2) = 0.18) was only indicated by harmonic regression analysis. CONCLUSIONS: P-wave duration, P area, and PR interval show a significant circadian variation in healthy subjects. The relations between P area/RR,PR/ RR, and P duration/RR also demonstrate a significant diurnal pattern. |
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Authors:
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P E Dilaveris; P Färbom; V Batchvarov; A Ghuran; M Malik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 6 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-02 Completed Date: 2001-07-26 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 92-7 Citation Subset: IM |
Affiliation:
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Department of Cardiological Sciences, St George's Hospital Medical School, London, England. hrodil@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Fibrillation / etiology Circadian Rhythm / physiology* Electrocardiography, Ambulatory* Female Heart Rate / physiology* Humans Male Middle Aged Reference Values Regression Analysis Risk Factors Signal Processing, Computer-Assisted Time Factors |
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