Document Detail

Circadian activity rhythms in rats with midbrain raphe lesions.
MedLine Citation:
PMID:  3779378     Owner:  NLM     Status:  MEDLINE    
The dorsal and median mesencephalic raphe nuclei provide a robust projection to the hypothalamic suprachiasmatic nucleus, the site of a putative neuronal circadian pacemaker. Although it has been suggested that the raphe may play a role in the circadian timing system, this role has not yet been specified. In the present report, we examined the circadian activity patterns of rats with large mid-brain lesions aimed at the median and dorsal raphe nuclei under conditions of light-dark entrainment, and while free-running in constant light and constant darkness. The results indicate that midbrain raphe lesions may interfere with the expression of free-running circadian activity rhythms.
J D Levine; A M Rosenwasser; J A Yanovski; N T Adler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  384     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-05     Completed Date:  1987-01-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  240-9     Citation Subset:  IM    
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MeSH Terms
Brain Mapping
Circadian Rhythm*
Mesencephalon / physiology*
Motor Activity / physiology*
Raphe Nuclei / physiology*
Rats, Inbred Strains
Serotonin / physiology
Suprachiasmatic Nucleus / physiology
Grant Support
Reg. No./Substance:

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