Document Detail

Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome.
MedLine Citation:
PMID:  23217262     Owner:  NLM     Status:  MEDLINE    
In the mouse liver, circadian transcriptional rhythms are necessary for metabolic homeostasis. Whether dynamic epigenomic modifications are associated with transcript oscillations has not been systematically investigated. We found that several antisense RNA, lincRNA, and microRNA transcripts also showed circadian oscillations in adult mouse livers. Robust transcript oscillations often correlated with rhythmic histone modifications in promoters, gene bodies, or enhancers, although promoter DNA methylation levels were relatively stable. Such integrative analyses identified oscillating expression of an antisense transcript (asPer2) to the gene encoding the circadian oscillator component Per2. Robust transcript oscillations often accompanied rhythms in multiple histone modifications and recruitment of multiple chromatin-associated clock components. Coupling of cycling histone modifications with nearby oscillating transcripts thus established a temporal relationship between enhancers, genes, and transcripts on a genome-wide scale in a mammalian liver. The results offer a framework for understanding the dynamics of metabolism, circadian clock, and chromatin modifications involved in metabolic homeostasis.
Christopher Vollmers; Robert J Schmitz; Jason Nathanson; Gene Yeo; Joseph R Ecker; Satchidananda Panda
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell metabolism     Volume:  16     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-22     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Circadian Rhythm / genetics*
DNA Methylation
Genetic Loci
Histones / genetics,  metabolism
Liver / metabolism*
Mice, Inbred C57BL
MicroRNAs / metabolism
Period Circadian Proteins / genetics,  metabolism
Promoter Regions, Genetic
RNA / metabolism*
RNA, Antisense / metabolism
RNA, Long Noncoding / metabolism
Transcription, Genetic / genetics*
Grant Support
DK091618/DK/NIDDK NIH HHS; F32 HG004830/HG/NHGRI NIH HHS; F32-HG004830/HG/NHGRI NIH HHS; GM084317/GM/NIGMS NIH HHS; HG004659/HG/NHGRI NIH HHS; NS075449/NS/NINDS NIH HHS; R01 DK091618/DK/NIDDK NIH HHS; R01 GM084317/GM/NIGMS NIH HHS; R01 HG004659/HG/NHGRI NIH HHS; R01 NS075449/NS/NINDS NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Histones; 0/MicroRNAs; 0/Per2 protein, mouse; 0/Period Circadian Proteins; 0/RNA, Antisense; 0/RNA, Long Noncoding; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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