| Circadian Feeding Drive of Metabolic Activity in Adipose Tissue and not Hyperphagia Triggers Overweight in Mice: Is There a Role of the Pentose-Phosphate Pathway? | |
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MedLine Citation:
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PMID: 22147018 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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High-fat (HF) diets trigger an increase in adipose tissue and body weight (BW) and disordered eating behavior. Our study deals with the hypothesis that circadian distribution of energy intake is more relevant for BW dynamics than diet composition. Four-week-old mice were exposed for 8 wk to a HF diet and compared with animals receiving control chow. HF mice progressively increased BW, decreased the amount of nocturnal (1800-0900 h) calories (energy or food intake) (30%) and increased diurnal (0900-1800 h) caloric intake (energy or food intake), although total daily intake was identical between groups. Animals were killed at 3-h intervals and plasma insulin, leptin, corticosterone, glucose, and fatty acid levels quantified. Adipose tissue was weighed, and enzymatic activities integral to the pentose phosphate pathway (PPP) assayed in lumbar adipose tissue. Phosphorylated AMP-dependent protein kinase and fatty acid synthase were quantified by Western blotting. In HF mice, there was a shift in the circadian oscillations of plasma parameters together with an inhibition of PPP activity and a decrease in phosphorylated AMP-dependent protein kinase and fatty acid synthase. In a second experiment, HF mice were forced to adhere to a circadian pattern of food intake similar to that in control animals. In this case, BW, adipose tissue, morning plasma parameters and PPP activity appeared to be normal. These data indicate that disordered feeding behavior can trigger BW gain independently of food composition and daily energy intake. Because PPP is the main source of reduced nicotinamide adenine dinucleotide phosphate, we suggest that PPP inhibition might be an early marker of adipose dysfunction in diet-induced obesity. |
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Authors:
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Paula Stucchi; Marta Gil-Ortega; Beatriz Merino; Rocío Guzmán-Ruiz; Victoria Cano; Ismael Valladolid-Acebes; Beatriz Somoza; Sophie Le Gonidec; Jesús Argente; Philippe Valet; Julie Ann Chowen; Marisol Fernández-Alfonso; Mariano Ruiz-Gayo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: Endocrinology Volume: - ISSN: 1945-7170 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Instituto Pluridisciplinar and Departamento de Farmacología (P.S., M.F.-A.), Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain; Departamento de Ciencias Farmacéuticas y de la Alimentación (M.G.-O., B.M., R.G.-R., V.C., I.V.-A., B.S., M.R.-G.), Facultad de Farmacia, Universidad Ceu-San Pablo, 28668 Madrid, Spain; Institut des Maladies Métaboliques et Cardiovasculaires (S.L.G., P.V.), I2MC Inserm-Université Paul Sabatier Unité Mixte de Recherche 1048, 31432 Toulouse, France; and Departamento de Endocrinología (J.A.), Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Universidad Autónoma de Madrid, Consorcio de Investigación Biomédica en Red de Obesidad y Nutrición Instituto Carlos III, 28009 Madrid, Spain. |
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