| Circadian dependence of infarct size and left ventricular function after ST elevation myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 22095727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE: In rodents, infarct size after ischemia/reperfusion exhibits a circadian dependence on the time of coronary occlusion. It is not known if a similar circadian dependence of infarct size occurs in humans. OBJECTIVE: To determine if humans exhibit a circadian dependence of infarct size in the setting of ST elevation myocardial infarction (STEMI). METHODS AND RESULTS: A retrospective analysis of 1031 patients with STEMI referred for primary percutaneous coronary intervention with known ischemic times between 1 and 6 hours identified 165 patients with occluded arteries on presentation without evidence of preinfarction angina or collateral blood flow. Both ischemic duration and angiographic area at risk were not dependent on time of infarct onset. We observed that the extent of infarct size measured by creatine kinase release was significantly associated with time of day onset of infarction (P<0.0001). The greatest myocardial injury occurred at 1:00 am onset of ischemia and 5:00 am onset of reperfusion, with the peak creatine kinase measured at the peak of the curve being 82% higher than that recorded at the trough. Similarly, left ventricular ejection fraction measured within 2 days of infarction was also dependent on time of onset of STEMI with the absolute left ventricular ejection fraction at peak >7% higher than at trough (43% vs 51%; P<0.03). These findings were supported by a subgroup of patients (n = 45) who underwent cardiac MRI measurements of infarct size and area-at-risk measurements. CONCLUSIONS: The results of this study demonstrate for the first time in humans that myocardial infarct size and left ventricular function after STEMI have a circadian dependence on the time of day onset of ischemia. |
| | |
Authors:
|
Ronald Reiter; Cory Swingen; Luke Moore; Timothy D Henry; Jay H Traverse |
Related Documents
:
|
9753797 - Canine and feline caval syndrome. 15338737 - Respiratory motion of the heart from free breathing coronary angiograms. 21996417 - Prognostic importance of atrial fibrillation in asymptomatic aortic stenosis: the simva... 21606087 - Burden of atherosclerosis improves the prediction of coronary heart disease but not cer... 16630087 - Fragmented left sided qrs in absence of bundle branch block: sign of left ventricular a... 8457647 - Elevated lipoprotein(a) is lowered by a cholesterol synthesis inhibitor in a normochole... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-17 |
Journal Detail:
|
Title: Circulation research Volume: 110 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-06 Completed Date: 2012-03-25 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
|
Languages: eng Pagination: 105-10 Citation Subset: IM |
Affiliation:
|
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN 55407, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Circadian Rhythm / physiology* Cohort Studies Creatine Kinase, MB Form / metabolism Electrocardiography* Female Humans Magnetic Resonance Imaging Male Middle Aged Myocardial Infarction / metabolism, pathology* Myocardial Reperfusion Injury / metabolism, pathology Retrospective Studies Ventricular Function, Left / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
1-RO1HL103927/HL/NHLBI NIH HHS; R01 HL103927-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.3.2/Creatine Kinase, MB Form |
| Comments/Corrections | |
Comment In:
|
Circ Res. 2012 Jan 6;110(1):6-7
[PMID:
22223205
]
Circ Res. 2012 Feb 3;110(3):e22; author reply e23 [PMID: 22302758 ] Circ Res. 2012 Apr 27;110(9):e67; author reply e68 [PMID: 22539760 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the he...
Next Document: Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate B...