| The Circadian Control of Skin and Cutaneous Photodamage(†). | |
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MedLine Citation:
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PMID: 22277067 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Biologically, light including ultraviolet (UV) radiations is vital for life. However, UV exposure does not come without risk, as it is a major factor in the development of skin cancer. Natural protections against UV damage may have been affected by lifestyle changes over the past century, including changes in our sun exposure due to working environments, and the use of sunscreens. In addition, extended 'day time' through the use of artificial light may contribute to the disruption of our circadian rhythms; the daily cycles of changes in critical bio-factors including gene expression. Circadian disruption has been implicated in many health conditions, including cardiovascular, metabolic, and psychiatric diseases, as well as many cancers. Interestingly, the pineal hormone melatonin plays a role in both circadian regulation, as well as protection from UV skin damage, and is therefore an important factor to consider when studying the impact of UV light. This review discusses the beneficial and deleterious effects of solar exposure, including UV skin damage, Vitamin D production, circadian rhythm disruption, and the impact of melatonin. Understanding of these benefits and risks is critical for the development of protective strategies against solar radiation. © 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology. |
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Authors:
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Joshua A Desotelle; Melissa J Wilking; Nihal Ahmad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Photochemistry and photobiology Volume: - ISSN: 1751-1097 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376425 Medline TA: Photochem Photobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 American Society for Photobiology. |
Affiliation:
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Department of Dermatology, University of Wisconsin, Madison, WI, USA University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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