| Ciprofloxacin versus ceftriaxone in the treatment of multiresistant typhoid fever. | |
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MedLine Citation:
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PMID: 8187784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomized trial comparing ceftriaxone (3 g given parenterally per day for 7 days) to ciprofloxacin (500 mg given orally twice a day for 7 days) in the treatment of blood culture positive typhoid fever was conducted. Twenty patients were openly randomized to receive ciprofloxacin and 22 to receive ceftriaxone. The outcome was classified as clinical failure in 6 patients (27%) in the ceftriaxone group, but in none in the ciprofloxacin group (p = 0.01). The mean duration of fever was four days in the ciprofloxacin group and about five days in the ceftriaxone group (p = 0.04). In the six patients in the ceftriaxone group who experienced failure, therapy was switched to ciprofloxacin and the patients became afebrile and asymptomatic within 48 hours. Patients with resistant strains of Salmonella typhi and patients with sensitive strains responded equally well to ciprofloxacin therapy. Analysis of a subset of 12 of the multiresistant strains revealed that resistance was encoded for by a transferable 180 kilobase plasmid. Ciprofloxacin represents a useful treatment option in areas where multiresistant strains are likely to be encountered. |
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Authors:
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M R Wallace; A A Yousif; G A Mahroos; T Mapes; E J Threlfall; B Rowe; K C Hyams |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 12 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-06-17 Completed Date: 1994-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: GERMANY |
Other Details:
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Languages: eng Pagination: 907-10 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Naval Hospital, San Diego, California 92134-5000. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteriophage Typing Ceftriaxone / therapeutic use* Ciprofloxacin / therapeutic use* Drug Resistance, Microbial Humans Treatment Outcome Typhoid Fever / drug therapy* |
| Chemical | |
Reg. No./Substance:
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73384-59-5/Ceftriaxone; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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