Document Detail


Ciprofloxacin shows synergism with classical antifungals against Histoplasma capsulatum var. capsulatum and Coccidioides posadasii.
MedLine Citation:
PMID:  23205615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study evaluated the in vitro interaction between ciprofloxacin (CIP) and classical antifungals against Histoplasma capsulatum var. capsulatum in mycelial (n = 16) and yeast-like forms (n = 9) and Coccidioides posadasii in mycelial form (n = 16). This research was conducted through broth microdilution and macrodilution, according to Clinical Laboratory Standards Institute. Inocula were prepared to obtain from 0.5 × 10(3) to 2.5 × 10(4)  cfu ml(-1) for H. capsulatum and from 10(3) to 5 × 10(3)  cfu ml(-1) for C. posadasii. Initially, minimum inhibitory concentration (MIC) for each drug alone was determined. Then, these MICs were used as the highest concentration for each drug during combination assays. The procedures were performed in duplicate. For all combination assays, MICs were defined as the lowest concentration capable of inhibiting 80% of visible fungal growth, when compared to the drug-free control. Drug interaction was evaluated by paired sample t-Student test. The obtained data showed a significant MIC reduction for most tested combinations of CIP with antifungals, except for that of CIP and voriconazole against yeast-like H. capsulatum. This study brings potential alternatives for the treatment of histoplasmosis and coccidioidomycosis, raising the possibility of using CIP as an adjuvant antifungal therapy, providing perspectives to delineate in vivo studies.
Authors:
R S N Brilhante; E P Caetano; J J C Sidrim; R A Cordeiro; Z P Camargo; M A B Fechine; R A C Lima; D S C M Castelo Branco; F J F Marques; J R L Mesquita; D T Lima; A J Monteiro; M F G Rocha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Mycoses     Volume:  -     ISSN:  1439-0507     ISO Abbreviation:  Mycoses     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
Affiliation:
Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza, Brazil Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Brazil Department of Microbiology, Immunology and Parasitology, São Paulo Federal University, São Paulo, Brazil São José Hospital, Fortaleza, Brazil Department of Statistics and Applied Mathematics, Federal University of Ceará, Fortaleza, Brazil Postgraduate Program in Veterinary Sciences, State University of Ceará, Fortaleza, Brazil.
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