Document Detail


Ciprofloxacin iontophoresis for aminoglycoside-resistant pseudomonal keratitis.
MedLine Citation:
PMID:  2210988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies using ciprofloxacin for the therapy of experimental aminoglycoside-resistant keratitis caused by Pseudomonas aeruginosa were conducted using transcorneal iontophoresis as the drug-delivery system. Corneas infected with P. aeruginosa ATCC 27853/pMG6 were treated 22 hours postinfection with ciprofloxacin delivered by iontophoresis (0.8 mA X 10 min), mock iontophoresis (eyecup with no current), or frequently applied topical drops. Iontophoresis of 10 mg/ml or 25 mg/ml of ciprofloxacin significantly reduced the number of viable bacteria per cornea by more than 5 log units compared with untreated controls (P less than 0.0001). Five hours after the initiation of treatment, mock iontophoresis (10 mg/ml or 25 mg/ml) or 11 applications of topical ciproflaxicin drops (7.5 mg/ml) decreased the viable bacteria relative to the untreated controls by 5 log units (P less than 0.0001). One treatment with an eyecup was as effective as 11 treatments with topical drops (P greater than 0.75). One hour after treatment with iontophoresis or mock iontophoresis of 10 mg/ml of ciprofloxacin, aqueous humor concentrations were 83.75 +/- 8.85 micrograms/ml and 24.87 +/- 4.0 micrograms/ml (mean +/- standard error of the mean), respectively. One hour after the last of five applications of 7.5 mg/ml of ciprofloxacin (every 15 min for 1 hr) the aqueous humor concentration was 4.2 +/- 1.14 micrograms/ml. These results show the value of ciprofloxacin in treating aminoglycoside-resistant infections caused by P. aeruginosa and suggest that ciprofloxacin can be efficiently delivered by iontophoresis.
Authors:
J A Hobden; J J Reidy; R J O'Callaghan; M S Insler; J M Hill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  31     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-13     Completed Date:  1990-11-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1940-4     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Louisiana State University Medical Center, New Orleans.
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides / therapeutic use*
Animals
Aqueous Humor / metabolism
Ciprofloxacin / administration & dosage*,  pharmacokinetics,  therapeutic use
Colony Count, Microbial
Drug Resistance, Microbial
Iontophoresis
Keratitis / etiology*
Osmolar Concentration
Pseudomonas Infections / drug therapy*,  microbiology
Rabbits
Grant Support
ID/Acronym/Agency:
EY-02377/EY/NEI NIH HHS; EY-07608/EY/NEI NIH HHS; EY-08871/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Aminoglycosides; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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