| Ciprofloxacin-induced acute liver injury: case report and review of literature. | |
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MedLine Citation:
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PMID: 14994731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ciprofloxacin is a fluorinated quinolone antibiotic with relatively low occurrence of adverse side effects. However, increasing evidence suggests that ciprofloxacin may cause severe liver damage. Until now, 14 cases of ciprofloxacin-associated liver injuries have been reported. We describe a case of a 22-year-old male who developed hepatic failure after intake of ciprofloxacin. The patient had been treated with 2 x 250 mg ciprofloxacin per day. He presented with symptoms of acute liver failure 14 days later. Liver biopsy revealed extensive hepatocellular necrosis involving zones 3 and 2 of hepatic acini and a mixed inflammatory infiltration containing abundant eosinophils. Symptoms resolved after corticoidsteroid therapy. In the present paper, we report the clinico-pathological characteristics of a case of ciprofloxacin-associated acute hepatic failure and discuss the current literature. |
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Authors:
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Annette Zimpfer; Albert Propst; Gregor Mikuz; Wolfgang Vogel; Luigi Terracciano; Sylvia Stadlmann |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 444 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-03-02 Completed Date: 2004-03-11 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 87-9 Citation Subset: IM |
Affiliation:
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Institute of Pathology, University of Basel, Schoenbeinstrasse 40, 4003 Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents / adverse effects* Biopsy Ciprofloxacin / adverse effects* Eosinophils / pathology Humans Liver / pathology Liver Failure, Acute / chemically induced*, drug therapy, pathology Male Methylprednisolone / therapeutic use Necrosis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 83-43-2/Methylprednisolone; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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