Document Detail

Ciprofloxacin-induced acute liver injury: case report and review of literature.
MedLine Citation:
PMID:  14994731     Owner:  NLM     Status:  MEDLINE    
Ciprofloxacin is a fluorinated quinolone antibiotic with relatively low occurrence of adverse side effects. However, increasing evidence suggests that ciprofloxacin may cause severe liver damage. Until now, 14 cases of ciprofloxacin-associated liver injuries have been reported. We describe a case of a 22-year-old male who developed hepatic failure after intake of ciprofloxacin. The patient had been treated with 2 x 250 mg ciprofloxacin per day. He presented with symptoms of acute liver failure 14 days later. Liver biopsy revealed extensive hepatocellular necrosis involving zones 3 and 2 of hepatic acini and a mixed inflammatory infiltration containing abundant eosinophils. Symptoms resolved after corticoidsteroid therapy. In the present paper, we report the clinico-pathological characteristics of a case of ciprofloxacin-associated acute hepatic failure and discuss the current literature.
Annette Zimpfer; Albert Propst; Gregor Mikuz; Wolfgang Vogel; Luigi Terracciano; Sylvia Stadlmann
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  444     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-02     Completed Date:  2004-03-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  87-9     Citation Subset:  IM    
Institute of Pathology, University of Basel, Schoenbeinstrasse 40, 4003 Basel, Switzerland.
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MeSH Terms
Anti-Infective Agents / adverse effects*
Ciprofloxacin / adverse effects*
Eosinophils / pathology
Liver / pathology
Liver Failure, Acute / chemically induced*,  drug therapy,  pathology
Methylprednisolone / therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents; 83-43-2/Methylprednisolone; 85721-33-1/Ciprofloxacin

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