| Ciprofloxacin or imipenem use correlates with resistance in Pseudomonas aeruginosa. | |
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MedLine Citation:
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PMID: 22346558 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship between ciprofloxacin or imipenem use and antimicrobial resistance in Pseudomonas aeruginosa. METHODS: A retrospective review of monthly antimicrobial susceptibility reports for ciprofloxacin (1988 to 1995) and imipenem (1987 to 1995) against P aeruginosa and hospital antimicrobial use records at a tertiary care teaching hospital in Winnipeg, Manitoba. Data were entered into a relational database, R:Base 4.5++, collated, transferred to a spreadsheet and subjected to linear regression analysis. The relationship between ciprofloxacin or imipenem use and resistance was assessed using a Pearson correlation. RESULTS: Ciprofloxacin-resistant P aeruginosa increased from 1.0% of all isolates in 1988 to 10.0% in 1995. A significant (P=0.05) correlation was demonstrated between the amount of ciprofloxacin use and prevalence of ciprofloxacin-resistant P aeruginosa (r=0.73, P=0.05). Imipenem-resistant P aeruginosa increased from 1.0% of isolates in 1987 to a maximum of 10.4% in 1991, and subsequently decreased to 5.4% in 1995. Imipenem use and the prevalence of imipenem-resistant P aeruginosa were significantly correlated (r=0.85, P=0.014). CONCLUSIONS: Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa. |
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Authors:
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G G Zhanel; L E Nicolle; A S Gin; J Karlowsky; A Kabani; D J Hoban |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses Volume: 9 ISSN: 1180-2332 ISO Abbreviation: Can J Infect Dis Publication Date: 1998 Nov |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-08-24 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 9425856 Medline TA: Can J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 382-6 Citation Subset: - |
Affiliation:
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Departments of Medicine and Medical Microbiology and Faculties of Medicine and Pharmacy, University of Manitoba; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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