| Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. | |
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MedLine Citation:
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PMID: 19937569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported earlier that dietary cinnamon extract (CE) improves systemic insulin sensitivity and dyslipidemia by enhancing insulin signaling. In the present study, we have examined the effects of CE on several biomarkers including plasma levels of adipose-derived adipokines, and the potential molecular mechanisms of CE in epididymal adipose tissue (EAT). In Wistar rats fed a high-fructose diet (HFD) to induce insulin resistance, supplementation with a CE (Cinnulin PF, 50 mg/kg daily) for 8 weeks reduced blood glucose, plasma insulin, triglycerides, total cholesterol, chylomicron-apoB48, VLDL-apoB100, and soluble CD36. CE also inhibited plasma retinol binding protein 4 (RBP4) and fatty acid binding protein 4 (FABP4) levels. CE-induced increases in plasma adiponectin were not significant. CE did not affect food intake, bodyweight, and EAT weight. In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4 , and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant. CE also enhanced the mRNA levels of ADIPOQ, and inhibited sterol regulatory element binding protein-1c mRNA levels. mRNA and protein levels of fatty acid synthase and FABP4 were inhibited by CE and RBP4, and CD36 protein levels were also decreased by CE. These results suggest that CE effectively ameliorates circulating levels of adipokines partially mediated via regulation of the expression of multiple genes involved in insulin sensitivity and lipogenesis in the EAT. |
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Authors:
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B Qin; M M Polansky; R A Anderson |
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Publication Detail:
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Type: Journal Article Date: 2009-11-23 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705, USA. Bolin.Qin@ars.usda.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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blood*,
genetics Adipose Tissue / drug effects, metabolism Animals Apolipoprotein B-48 / blood Blood Glucose / metabolism Carbohydrate Metabolism / drug effects, genetics* Chylomicrons / metabolism Cinnamomum zeylanicum / chemistry* Diet Epididymis / drug effects, metabolism Feeding Behavior / drug effects Fructose / administration & dosage, pharmacology* Gene Expression Regulation / drug effects* Glucose / metabolism Insulin / metabolism Lipogenesis / drug effects, genetics* Male Plant Extracts / pharmacology* RNA, Messenger / genetics, metabolism Rats Rats, Wistar Signal Transduction / drug effects, genetics |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/Apolipoprotein B-48; 0/Blood Glucose; 0/Chylomicrons; 0/Plant Extracts; 0/RNA, Messenger; 11061-68-0/Insulin; 30237-26-4/Fructose; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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