| Cinnamaldehyde Prevents Adipocyte Differentiation and Adipogenesis via Regulating PPAR-γ and AMPK Pathways. | |
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MedLine Citation:
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PMID: 21401097 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cinnamaldehyde (CA), one of the active components of cinnamon, has been known to exert several pharmacological effects such as anti-inflammatory, antioxidant, anti-tumor and anti-diabetic activities. However, its anti-obesity effect has not been reported yet. We investigated the anti-differentiation effect of CA on 3T3-L1 preadipocytes, and anti-obese activity of CA was further explored using a high fat diet-induced obese ICR mice. During 3T3-L1 preadipocytes were differentiated into adipocytes, 10 to 40 μM of CA was treated and lipid contents were quantified by Oil-Red O staining, along with changes in the expression of genes and proteins associated with adipocyte differentiation and adipogenesis. It was found that CA significantly reduced the lipid accumulation and down-regulated the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ), CCAAT/enhancer-binding proteins α(C/EBPα) and sterol regulatory element-binding protein 1 (SREBP1) in concentration-dependent manners. Moreover, CA markedly up-regulated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), and these effects were blunted in the presence of AMPK inhibitor, compound C. In animal study, we found that weight gains, insulin resistance index, plasma triglyceride (TG), non-esterified fatty acid (NEFA) and cholesterol levels in 40 mg/kg of CA-administered group were significantly decreased by 67.3%, 55%, 39%, 31% and 23%, respectively, when compared to high fat diet control group. In summary, these results suggest that CA exerts anti-adipogenic effects through modulation of the PPAR-γ and AMPK signaling pathways. |
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Authors:
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Bo Huang; Hai Dan Yuan; Do Yeon Kim; Hai Yan Quan; Sung Hyun Chung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-14 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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