Document Detail

Cingulate epileptogenesis in hypothalamic hamartoma.
MedLine Citation:
PMID:  21480885     Owner:  NLM     Status:  Publisher    
Hypothalamic hamartoma (HH) is a relatively rare cause of epilepsy, mainly affecting children. Nearly all patients develop gelastic seizures, often followed by other focal seizure types. Our case illustrates the mechanisms of epileptogenesis in HH. The patient developed gelastic attacks as a baby, and secondarily generalized seizures and drop attacks at 9 years of age. Magnetic resonance imaging (MRI) confirmed the presence of a HH. Presurgical assessment with intracranial electroencephalography (EEG) monitoring recorded gelastic seizures with generalized epileptiform activity. Functional stimulation of the hamartoma provoked gelastic attacks. Single pulse electrical stimulation (SPES) was used to identify epileptogenic cortex. SPES of the left cingular cortex provoked generalized responses similar to the spontaneous generalized discharges. Our results suggest that long-standing history of epilepsy in patients with HH may be related to additional sources of epileptogenic activity. Electrical stimulation performed in this patient provided additional data to favor the hypothesis of secondarily epileptogenesis in the cingulate gyrus independently from the primary origin in the HH.
Antonio Valentin; Marian Lazaro; Nandini Mullatti; Sebastian Cervantes; Irfan Malik; Richard P Selway; Gonzalo Alarcón
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom Department of Clinical Neurophysiology, King's College Hospital NHS Foundation Trust, London, United Kingdom Neurophysiology Department, Queen Elizabeth Hospital, Birmingham, United Kingdom Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, United Kingdom.
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