Document Detail


Cinematographic study of the effects of cis-diammine-dichloroplatinum on mouse L cells.
MedLine Citation:
PMID:  6542178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells of mouse fibroblasts line L were grown one hour in the presence of cisplatin. Their fate was then followed by time-lapse microcinematography during six days. Up to the concentration 3.2 mumol 1(-1) there was little effect observed. Higher concentrations induced prolongation of mitosis and interphase, finally resulting in non-cycling cells with complete and persistent division arrest at 25 mumol 1(-1). After 72 hours following the treatment the cellular and nuclear volumes in non-cycling cells began to grow progressively. The mobility and the ruffling activity of the cell membrane were unaltered. Thus, energy generation, the function of the cytoskeleton, and synthetic processes seemed unchanged. The effect of cisplatin is cytostatic rather than cytotoxic.
Authors:
M Cervinka; J Drobník
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  31     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-16     Completed Date:  1985-01-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  521-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / drug effects
Cell Survival / drug effects
Cisplatin / pharmacology*
L Cells (Cell Line) / cytology,  drug effects*
Mice
Photography
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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