| Cinematographic study of the effects of cis-diammine-dichloroplatinum on mouse L cells. | |
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MedLine Citation:
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PMID: 6542178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells of mouse fibroblasts line L were grown one hour in the presence of cisplatin. Their fate was then followed by time-lapse microcinematography during six days. Up to the concentration 3.2 mumol 1(-1) there was little effect observed. Higher concentrations induced prolongation of mitosis and interphase, finally resulting in non-cycling cells with complete and persistent division arrest at 25 mumol 1(-1). After 72 hours following the treatment the cellular and nuclear volumes in non-cycling cells began to grow progressively. The mobility and the ruffling activity of the cell membrane were unaltered. Thus, energy generation, the function of the cytoskeleton, and synthetic processes seemed unchanged. The effect of cisplatin is cytostatic rather than cytotoxic. |
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Authors:
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M Cervinka; J Drobník |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neoplasma Volume: 31 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1984 |
Date Detail:
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Created Date: 1985-01-16 Completed Date: 1985-01-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 521-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects Cell Survival / drug effects Cisplatin / pharmacology* L Cells (Cell Line) / cytology, drug effects* Mice Photography |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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