Document Detail


Cinacalcet treatment for secondary hyperparathyroidism in dialysis patients: an observational study in routine clinical practice.
MedLine Citation:
PMID:  21150219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cinacalcet reduces intact parathyroid hormone (iPTH), Ca and P serum levels in patients with secondary hyperparathyroidism (SHPT).
METHODS: This Spanish, multicenter, observational, retrospective study collected data from SHPT dialysis patients 12 weeks before and up to 72 weeks after starting cinacalcet in clinical practice.
RESULTS: Data from 428 patients with uncontrolled SHPT despite receiving standard of care (29% with baseline iPTH 501-800 pg/ml; 51% with >800 pg/ml) were collected. Percentages of patients within National Kidney Foundation Kidney Disease Outcomes Quality Initiative targets at baseline and 72 weeks were: iPTH, 0 versus 32.5% (p < 0.05); Ca, 40.1 versus 50% (p < 0.05); P, 47.7 versus 53.8% (p = 0.162). Vitamin D sterol use decreased from 53.3% at baseline to 36.7% at 72 weeks (p < 0.05). The mean ± SD cinacalcet dose at 72 weeks was 44.0 ± 25.8, 51.7 ± 31.3 and 57.1 ± 37.0 mg for patients with baseline iPTH 301-500, 501-800 or >800 pg/ml, respectively. The main adverse reactions were nausea (5.4%), dyspepsia (5.1%) and vomiting (3.7%).
CONCLUSIONS: The introduction of cinacalcet improved the routine clinical management of SHPT in a large cohort of Spanish dialysis patients. Cinacalcet is effective and well tolerated regardless of disease severity, and maintains its efficacy over 72 weeks.
Authors:
Jordi Bover; Rafael Perez; Manuel Molina; Beatriz Benavides; Francisco Ariza; José Luis Miguel; Fernando Tornero; Josep Vicens Torregrosa;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-12-10
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  118     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-24     Completed Date:  2012-05-07     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c109-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Fundació Puigvert, Barcelona, España.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Humans
Hyperparathyroidism, Secondary / blood,  drug therapy*,  therapy
Male
Middle Aged
Naphthalenes / therapeutic use*
Parathyroid Hormone / blood
Renal Dialysis*
Retrospective Studies
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Naphthalenes; 0/Parathyroid Hormone; UAZ6V7728S/cinacalcet
Investigator
Investigator/Affiliation:
Enric Andres Ribes / ; Alejandro Martín Malo / ; Maria Asunción Galicia Basart / ; Clotilde Rios Camacho / ; Maria Carmen Sánchez Perales / ; Francisco Coronel / ; Higinio Cao Baduell / ; Alberto Martínez Castelao / ; Amparo Bernat García / ; Dolores Arenas Jiménez / ; Rafa Díaz-Tejeiro Izquierdo / ; Antonio Molina / ; Jesús Olivares Martín / ; Ángel Luis Martín de Francisco / ; Aurora Lopez Montes / ; Lopez Montes Chivite / ; Maria Del Mar Castilla Castellano / ; Jesús Bustamante Bustamente / ; José María Graña Fandos / ; Francisco Javier Moncalian León / ; Guillermo Martín Reyes / ; Joan Feixas Roma / ; Enrique Vicente Albert Balaguer / ; Emilio Gonzalez Parra / ; Marisa Alcalá Rueda / ; Gloria Martin / ; Rafael Pérez Mijares Pérez / ; Julián García De Diego / ; César González Martínez / ; Andrés Antolín Cariñena / ; Domingo Sánchez-Guisande Jack / ; Víctor Lorenzo / ; Jorge Reichert / ; Marta Luzón / ; Carlos Santiago /

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