Document Detail

Cimetidine, vasopressin and chronotropic incompetence.
MedLine Citation:
PMID:  6983645     Owner:  NLM     Status:  MEDLINE    
A 59-year-old man with severe variceal bleeding received therapy with intravenously administered vasopressin and cimetidine. Inappropriate bradycardia, sinoatrial and atrioventricular blocks, and terminal bradycardia leading to asystole, occurred during bleeding, with the greatest number of rhythm abnormalities occurring during combined cimetidine and vasopressin therapy. The results of post-mortem examination showed only mild coronary artery disease. The hazards of combined vasopressin and cimetidine therapy are reviewed.
G Nikolic; J B Singh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  2     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  435-6     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / chemically induced*
Bradycardia / chemically induced
Cimetidine / administration & dosage,  adverse effects*
Coronary Disease / complications,  pathology
Drug Therapy, Combination
Esophageal and Gastric Varices / drug therapy
Gastrointestinal Hemorrhage / drug therapy
Guanidines / adverse effects*
Heart Block / chemically induced
Middle Aged
Vasopressins / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Guanidines; 11000-17-2/Vasopressins; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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