| Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit. | |
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MedLine Citation:
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PMID: 3874573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. Endoscopy showed that 14 of 21 patients treated with cimetidine, compared with 5 of 18 patients treated with placebo, had normal or improved gastroduodenal mucosa (p less than 0.05). Endoscopic signs of bleeding cleared or did not develop in 20 patients treated with cimetidine and in 11 patients treated with placebo (p less than 0.01). Significantly fewer blood transfusions were given to patients with endoscopic signs of bleeding in the cimetidine-treated group (0.5 +/- 0.3 [SE] units) than in placebo-treated patients (4.5 +/- 1.5 units; p less than 0.05). The mortality rate was not statistically different between treatment groups. By preventing established gastroduodenal stress lesions from progressing in severity, cimetidine diminished both bleeding and the need for transfusions. |
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Authors:
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D A Peura; L F Johnson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of internal medicine Volume: 103 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-08-07 Completed Date: 1985-08-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Transfusion Cimetidine / therapeutic use* Critical Care Double-Blind Method Duodenal Diseases / drug therapy, etiology, prevention & control* Duodenum / drug effects, pathology Endoscopy Female Gastric Mucosa / drug effects, pathology Gastritis / prevention & control Gastrointestinal Hemorrhage / prevention & control Humans Intestinal Mucosa / drug effects, pathology Male Middle Aged Peptic Ulcer / prevention & control Random Allocation Stomach Diseases / drug therapy, etiology, prevention & control* Stress, Physiological / complications |
| Chemical | |
Reg. No./Substance:
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51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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