Document Detail

Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit.
MedLine Citation:
PMID:  3874573     Owner:  NLM     Status:  MEDLINE    
The efficacy of cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. Endoscopy showed that 14 of 21 patients treated with cimetidine, compared with 5 of 18 patients treated with placebo, had normal or improved gastroduodenal mucosa (p less than 0.05). Endoscopic signs of bleeding cleared or did not develop in 20 patients treated with cimetidine and in 11 patients treated with placebo (p less than 0.01). Significantly fewer blood transfusions were given to patients with endoscopic signs of bleeding in the cimetidine-treated group (0.5 +/- 0.3 [SE] units) than in placebo-treated patients (4.5 +/- 1.5 units; p less than 0.05). The mortality rate was not statistically different between treatment groups. By preventing established gastroduodenal stress lesions from progressing in severity, cimetidine diminished both bleeding and the need for transfusions.
D A Peura; L F Johnson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of internal medicine     Volume:  103     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-08-07     Completed Date:  1985-08-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion
Cimetidine / therapeutic use*
Critical Care
Double-Blind Method
Duodenal Diseases / drug therapy,  etiology,  prevention & control*
Duodenum / drug effects,  pathology
Gastric Mucosa / drug effects,  pathology
Gastritis / prevention & control
Gastrointestinal Hemorrhage / prevention & control
Intestinal Mucosa / drug effects,  pathology
Middle Aged
Peptic Ulcer / prevention & control
Random Allocation
Stomach Diseases / drug therapy,  etiology,  prevention & control*
Stress, Physiological / complications
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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