Document Detail

Cimetidine preserves non-specific immune function after colonic resection for cancer.
MedLine Citation:
PMID:  7980260     Owner:  NLM     Status:  MEDLINE    
Fifty consecutive patients undergoing resection of colorectal cancer were randomized to either receive cimetidine at a dose of 400 mg bd for a minimum of 5 pre-operative days, then intravenously for 2 postoperative days, or to act as controls. Baseline immune function was determined in all patients by in vitro testing of lymphocyte proliferation (LP) in response to mitogen, skin testing for cell mediated immunity (CMI) and measurement of lymphocyte subsets. Immune function was retested in both groups on the second postoperative day. In control patients the mean postoperative LP value was 41% of pre-operative levels (P < 0.0001) and the mean CMI reduced to 29% (P < 0.0001). Patients treated with cimetidine had no significant fall in these parameters. Numbers of T and natural killer (NK) cells fell after surgery in both groups, and B cell numbers were maintained in the cimetidine group. It is concluded that cimetidine reduces the immunosuppression that follows colonic resection.
W J Adams; D L Morris; W B Ross; D Z Lubowski; D W King; L Peters
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian and New Zealand journal of surgery     Volume:  64     ISSN:  0004-8682     ISO Abbreviation:  Aust N Z J Surg     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373115     Medline TA:  Aust N Z J Surg     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
Department of Surgery, St George Hospital, Kogarah, New South Wales, Australia.
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MeSH Terms
Cimetidine / administration & dosage,  therapeutic use*
Colorectal Neoplasms / immunology*,  surgery*
Immunity, Cellular
Lymphocyte Activation
Lymphocyte Subsets / immunology
Middle Aged
Mitogens / pharmacology
Reg. No./Substance:
0/Mitogens; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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