Document Detail

Cimetidine and the potential risk of postoperative sepsis.
MedLine Citation:
PMID:  7272673     Owner:  NLM     Status:  MEDLINE    
The gastric microflora of patients receiving cimetidine for duodenal ulceration has been investigated and the results compared with those from a group of untreated patients. Cimetidine-induced hypochlorhydria allows bacterial proliferation in the stomach; 75 per cent of aspirates from 44 fasting patients taking cimetidine 1 g daily were found to contain bacteria 2--4 h after the last dose. Of 41 patients taking cimetidine 400 mg at night, 34 per cent still had bacteria in their aspirates 12--13 h later. Patients treated with cimetidine are likely to be at an increased risk of postoperative sepsis. The drug should either be withdrawn before gastric surgery is undertaken or patients with gastric contents of pH 4 or above should receive antibiotic cover.
T J Muscroft; D Youngs; D W Burdon; M R Keighley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  68     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-9     Citation Subset:  AIM; IM    
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MeSH Terms
Bacteria / isolation & purification
Cimetidine / adverse effects*,  therapeutic use
Duodenal Ulcer / drug therapy,  microbiology
Guanidines / adverse effects*
Hydrogen-Ion Concentration
Middle Aged
Stomach / microbiology
Surgical Wound Infection / etiology*
Reg. No./Substance:
0/Guanidines; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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