| Cimetidine and the potential risk of postoperative sepsis. | |
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MedLine Citation:
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PMID: 7272673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastric microflora of patients receiving cimetidine for duodenal ulceration has been investigated and the results compared with those from a group of untreated patients. Cimetidine-induced hypochlorhydria allows bacterial proliferation in the stomach; 75 per cent of aspirates from 44 fasting patients taking cimetidine 1 g daily were found to contain bacteria 2--4 h after the last dose. Of 41 patients taking cimetidine 400 mg at night, 34 per cent still had bacteria in their aspirates 12--13 h later. Patients treated with cimetidine are likely to be at an increased risk of postoperative sepsis. The drug should either be withdrawn before gastric surgery is undertaken or patients with gastric contents of pH 4 or above should receive antibiotic cover. |
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Authors:
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T J Muscroft; D Youngs; D W Burdon; M R Keighley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 68 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-11-24 Completed Date: 1981-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 557-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bacteria / isolation & purification Cimetidine / adverse effects*, therapeutic use Duodenal Ulcer / drug therapy, microbiology Female Guanidines / adverse effects* Humans Hydrogen-Ion Concentration Male Middle Aged Risk Stomach / microbiology Surgical Wound Infection / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Guanidines; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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