Document Detail


Cimetidine and the potential risk of postoperative sepsis.
MedLine Citation:
PMID:  7272673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastric microflora of patients receiving cimetidine for duodenal ulceration has been investigated and the results compared with those from a group of untreated patients. Cimetidine-induced hypochlorhydria allows bacterial proliferation in the stomach; 75 per cent of aspirates from 44 fasting patients taking cimetidine 1 g daily were found to contain bacteria 2--4 h after the last dose. Of 41 patients taking cimetidine 400 mg at night, 34 per cent still had bacteria in their aspirates 12--13 h later. Patients treated with cimetidine are likely to be at an increased risk of postoperative sepsis. The drug should either be withdrawn before gastric surgery is undertaken or patients with gastric contents of pH 4 or above should receive antibiotic cover.
Authors:
T J Muscroft; D Youngs; D W Burdon; M R Keighley
Related Documents :
11448093 - Effect of naloxone therapy on depersonalization: a pilot study.
11743243 - Gastroparesis after combined heart and lung transplantation.
24082663 - Optic nerve hypoplasia.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  68     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bacteria / isolation & purification
Cimetidine / adverse effects*,  therapeutic use
Duodenal Ulcer / drug therapy,  microbiology
Female
Guanidines / adverse effects*
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Risk
Stomach / microbiology
Surgical Wound Infection / etiology*
Chemical
Reg. No./Substance:
0/Guanidines; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cholecystectomy and cancer of the large bowel.
Next Document:  The microflora of the postoperative stomach.