| Cimetidine and postprandial pancreatic exocrine secretion in dogs. | |
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MedLine Citation:
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PMID: 2420160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In dogs fitted with a pancreatic cannula and a duodenal cannula the intake of a standard meal induced a significant increase in the flow of pancreatic secretion and in the output of amylase, total protein, bicarbonate and chloride. The oral administration (200 mg/day) of cimetidine to dogs was seen to elicit a marked decrease in postprandial flow increase and bicarbonate output, coinciding with a significant increase in amylase and total protein output. At the same time the postprandial duodenal pH remained at levels similar to those obtained in basal periods. The implications of secretin, gastrin and cholecystokinin (CCK) on these effects are discussed. |
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Authors:
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J A Madrid; G M Salido; E Martinez de Victoria; F J Mataix |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 17 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-03-31 Completed Date: 1986-03-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 145-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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secretion Animals Bicarbonates / secretion Chlorides / secretion Cimetidine / pharmacology* Dogs Eating Female Male Pancreatic Juice / drug effects, enzymology, secretion* Proteins / secretion Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Chlorides; 0/Proteins; 51481-61-9/Cimetidine; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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