Document Detail


Cimetidine-induced galactorrhea.
MedLine Citation:
PMID:  2719015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various breast abnormalities have been described in patients treated chronically with cimetidine, but galactorrhea has been reported only twice in the medical literature. In both cases, there appeared to be an associated hyperprolactinemia. These problems could well represent a consequence of histamine2-receptor blockade. We report here a female patient with hepatic cirrhosis and portal hypertension who developed hyperprolactinemia and galactorrhea while on long-term cimetidine therapy. Both the hyperprolactinemia and the galactorrhea disappeared when the patient was switched to ranitidine, an alternative H2-receptor blocker. A review of the previous case reports and relevant literature is included.
Authors:
M N Ehrinpreis; R Dhar; A Narula
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  84     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-13     Completed Date:  1989-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Wayne State University, Detroit, Michigan.
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MeSH Terms
Descriptor/Qualifier:
Cimetidine / adverse effects*
Female
Galactorrhea / chemically induced*
Humans
Lactation Disorders / chemically induced*
Middle Aged
Chemical
Reg. No./Substance:
51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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