Document Detail

Cimetidine in the treatment of interstitial cystitis.
MedLine Citation:
PMID:  7941209     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the effect of the H2-antagonist cimetidine in the treatment of patients with interstitial cystitis (IC) refractory to other conservative therapies. METHODS: A group of 9 patients previously treated conservatively for IC without success were entered in the study. They were thoroughly investigated and treated with cimetidine at the dose of 300 mg orally twice a day for 1 month. RESULTS: Six of the 9 patients (66%) experienced various degrees of symptomatic relief while on the drug. Of these, 4 (44%) have noted a complete and sustained response to the medication. CONCLUSIONS: The encouraging results observed in this pilot study together with the simplicity and tolerance of the treatment makes it an alternative when other options have been exhausted. Its use as a first-line monotherapy remains speculative.
P Seshadri; L Emerson; A Morales
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urology     Volume:  44     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-08     Completed Date:  1994-11-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  614-6     Citation Subset:  IM    
Department of Urology, Queen's University, Kingston, Ontario, Canada.
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MeSH Terms
Administration, Oral
Chronic Disease
Cimetidine / therapeutic use*
Cystitis / drug therapy*,  etiology,  pathology,  physiopathology
Follow-Up Studies
Pilot Projects
Time Factors
Treatment Outcome
Urinary Bladder / pathology
Reg. No./Substance:
Comment In:
Urology. 1995 Jun;45(6):1088   [PMID:  7771018 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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