Document Detail

Cimetidine in labour: absence of adverse effect on the high-risk fetus.
MedLine Citation:
PMID:  3886004     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized trial, 36 women received cimetidine and 32 magnesium trisilicate mixture BP as antacid therapy every 2 h in labour. The women belonged to a high-risk category and the infants born were less than 36 weeks gestation, or less than 2000 g birthweight or otherwise in jeopardy because of severe maternal pre-eclampsia or diabetes. Measurements of a wide range of haematological and biochemical variables revealed no differences between the two groups of babies. The frequency of complications found in the infants was similar, although infants born to the women who received magnesium trisilicate required oxygen therapy for a longer period. Cimetidine did not appear to affect the development of gastric acidity, or to increase bacterial colonization of the gastrointestinal tract in the infant.
D M McAuley; H L Halliday; J R Johnston; J Moore; J W Dundee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  92     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  350-5     Citation Subset:  AIM; IM    
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MeSH Terms
Cimetidine / adverse effects*,  therapeutic use
Clinical Trials as Topic
Fetus / drug effects*
Gastric Acid / secretion
Infant, Newborn
Magnesium / therapeutic use
Magnesium Silicates*
Obstetric Labor Complications / drug therapy*
Prospective Studies
Random Allocation
Silicic Acid / therapeutic use
Reg. No./Substance:
0/Magnesium Silicates; 1343-98-2/Silicic Acid; 14987-04-3/magnesium trisilicate; 51481-61-9/Cimetidine; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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