| Cimetidine in labour: absence of adverse effect on the high-risk fetus. | |
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MedLine Citation:
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PMID: 3886004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective randomized trial, 36 women received cimetidine and 32 magnesium trisilicate mixture BP as antacid therapy every 2 h in labour. The women belonged to a high-risk category and the infants born were less than 36 weeks gestation, or less than 2000 g birthweight or otherwise in jeopardy because of severe maternal pre-eclampsia or diabetes. Measurements of a wide range of haematological and biochemical variables revealed no differences between the two groups of babies. The frequency of complications found in the infants was similar, although infants born to the women who received magnesium trisilicate required oxygen therapy for a longer period. Cimetidine did not appear to affect the development of gastric acidity, or to increase bacterial colonization of the gastrointestinal tract in the infant. |
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Authors:
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D M McAuley; H L Halliday; J R Johnston; J Moore; J W Dundee |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 92 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-06-17 Completed Date: 1985-06-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 350-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cimetidine / adverse effects*, therapeutic use Clinical Trials as Topic Female Fetus / drug effects* Gastric Acid / secretion Humans Infant, Newborn Magnesium / therapeutic use Magnesium Silicates* Obstetric Labor Complications / drug therapy* Pregnancy Prospective Studies Random Allocation Risk Silicic Acid / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Magnesium Silicates; 1343-98-2/Silicic Acid; 14987-04-3/magnesium trisilicate; 51481-61-9/Cimetidine; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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