Document Detail

Cimetidine as pre-anesthetic agent for cesarean section: perinatal effects on the infant, the placental transfer of cimetidine and its elimination in the infants.
MedLine Citation:
PMID:  4057034     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized study of 39 consecutive cesarean sections, 20 patients received cimetidine 400 mg intramuscularly as a pre-anesthetic, an 19 control patients were given NaCl. No perinatal effects on the infants were observed by cardiotocography before delivery, and K, Na, pH, PCO2, HCO-3 and glucose values in capillary blood were nearly identical in the two groups 2 hours after birth, the difference being non-significant (p greater than 0.05). No respiratory effects or arrhythmias were observed. In another study comprising 8 elective cesarean sections in patients with uncomplicated pregnancies, cimetidine was found to cross the placenta at a maternal/cord blood ratio of 3:1. The drug could not be detected in any of the infants 2 hours after delivery.
N Qvist; K Storm; A Holmskov
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  13     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-29     Completed Date:  1985-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
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MeSH Terms
Cesarean Section*
Cimetidine / adverse effects,  blood*,  therapeutic use
Double-Blind Method
Infant, Newborn*
Maternal-Fetal Exchange*
Preanesthetic Medication*
Prospective Studies
Umbilical Veins
Reg. No./Substance:

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