Document Detail

Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis.
MedLine Citation:
PMID:  6908433     Owner:  NLM     Status:  MEDLINE    
The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied. Although both doses of Cimetidine reduced the acid secretion significantly, no reduction in the steatorrhea and creatorrhea or increase in weight were found, although less pancreatin seemed to be inactivated while on cimetidine. It is concluded that pancreatic extract supplementation alone is not sufficient to normalise the digestion in cystic fibrosis.
F de Biéville; H J Neijens; J Fernandes; M van Caillie; K F Kerrebijn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  70     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Body Weight
Celiac Disease / drug therapy
Cimetidine / therapeutic use*
Cystic Fibrosis / drug therapy*
Drug Therapy, Combination
Feces / analysis
Gastric Acid / drug effects
Guanidines / therapeutic use*
Intestinal Absorption / drug effects
Lipids / analysis
Malabsorption Syndromes / drug therapy*,  etiology
Nitrogen / analysis
Pancreatin / therapeutic use*
Secretory Rate / drug effects
Reg. No./Substance:
0/Guanidines; 0/Lipids; 51481-61-9/Cimetidine; 7727-37-9/Nitrogen; 8049-47-6/Pancreatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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