Document Detail

Cimetidine - antacid combination as premedication for elective Caesarean section.
MedLine Citation:
PMID:  6640395     Owner:  NLM     Status:  MEDLINE    
The effect of premedication with an oral antacid (magnesium trisilicate), oral cimetidine or a combination of both was studied in 80 patients undergoing elective Caesarean section. Twenty patients served as untreated controls. Seventy per cent of the patients were in the high risk range for acid aspiration pneumonitis (pH less than 2.5 plus gastric content volume greater than 25 ml). Antacid therapy was effective in raising pH but the gastric volume remained high in 50 per cent of the patients. Cimetidine was effective in decreasing gastric volume and raising pH but the pH was still less than 2.5 in two patients. None of the patients given the cimetidine-antacid combination were in the high risk range for acid aspiration pneumonitis. The combination of an oral dose of cimetidine 400 mg, three to four hours before the operation followed by 20 ml of magnesium trisilicate one hour preoperatively proved to be the most efficacious regimen for prophylaxsis against Mendelson's syndrome in elective Caesarean section. Recent reports have suggested that non-particulate antacids (e.g., sodium citrate) may be preferable to particulate antacids such as magnesium trisilicate.
A S Okasha; M M Motaweh; A Bali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  30     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  593-7     Citation Subset:  IM    
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MeSH Terms
Antacids / therapeutic use*
Cesarean Section*
Cimetidine / therapeutic use*
Drug Therapy, Combination
Gastric Juice / drug effects
Hydrogen-Ion Concentration
Middle Aged
Preanesthetic Medication*
Reg. No./Substance:
0/Antacids; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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