Document Detail

Cimetidine. I. Developments, pharmacology, and efficacy.
MedLine Citation:
PMID:  6751184     Owner:  NLM     Status:  MEDLINE    
Cimetidine therapy has proved to be effective in healing most duodenal ulcers and in reducing the frequency of reulceration. It is unclear if low-dose maintenance therapy is superior to intermittent full-dose therapy in managing patients whose ulcers recur. Cimetidine is the preferred treatment for patients with the Zollinger-Ellison syndrome, and current evidence indicates efficacy in healing benign gastric ulcers. Some patients with reflux esophagitis improve with cimetidine treatment, but the drug cannot be regarded as first-time therapy. Largely circumstantial evidence suggests a role in preventing bleeding from acute gastric erosions and in preventing the acid aspiration syndrome. Cimetidine therapy has not been found to be useful in controlling acute upper gastrointestinal hemorrhage, acute pancreatitis, or several other conditions for which H2 blockade has been advocated.
J W Freston
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of internal medicine     Volume:  97     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-80     Citation Subset:  AIM; IM    
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MeSH Terms
Chemical Phenomena
Cimetidine* / therapeutic use
Duodenal Ulcer / drug therapy
Esophagitis, Peptic / drug therapy
Gastric Acid / secretion
Gastrointestinal Hemorrhage / drug therapy
Pancreatitis / drug therapy
Pneumonia, Aspiration / prevention & control
Receptors, Histamine H2 / drug effects
Stomach Ulcer / drug therapy
Zollinger-Ellison Syndrome / drug therapy
Reg. No./Substance:
0/Guanidines; 0/Receptors, Histamine H2; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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