Document Detail

Cilostazol reduces target lesion revascularization after percutaneous transluminal angioplasty in the femoropopliteal artery.
MedLine Citation:
PMID:  16195627     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although percutaneous transluminal angioplasty (PTA) is being widely used for the treatment of stenosis of peripheral arteries, the high in-stent restenosis rate (50-60%) in the femoropopliteal artery still remains an unsolved issue. Cilostazol is a unique antiplatelet drug that has vasodilatory effects and inhibits smooth muscle cell proliferation.
METHODS AND RESULTS: A total of 141 consecutive patients scheduled for PTA in the femoropopliteal artery between September 1999 and April 2004 were retrospectively analyzed for the use of cilostazol. Target lesion revascularization (TLR) was defined as repeated PTA in patients who had a recurrence of symptoms with diameter stenosis >50% by angiography. Patient and lesion characteristics were similar between the cilostazol (+) and cilostazol (-) groups. Use of other medications was similar between the groups, except for ticlopidine, which was more frequently used in the cilostazol (-) than in the cilostazol (+) group (15% vs 61%, p<0.01). TLR was significantly reduced in the cilostazol (+) group (12% [8/68] vs 32% [23/73], p<0.01).
CONCLUSIONS: Although this study was retrospective and nonrandomized, the results suggest that cilostazol reduces TLR after PTA in the femoropopliteal artery.
Osamu Iida; Shinsuke Nanto; Masaaki Uematsu; Takakazu Morozumi; Jun-Ichi Kotani; Masaki Awata; Toshinari Onishi; Noriaki Ito; Fusako Oshima; Hitoshi Minamiguchi; Masafumi Kitakaze; Seiki Nagata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  69     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-30     Completed Date:  2005-12-09     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1256-9     Citation Subset:  IM    
Kansai Rosai Hospital, Amagasaki, Japan.
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MeSH Terms
Angioplasty, Balloon* / methods
Cell Proliferation / drug effects
Femoral Artery* / surgery
Graft Occlusion, Vascular / drug therapy*,  metabolism
Myocytes, Smooth Muscle / metabolism
Platelet Aggregation Inhibitors / administration & dosage*
Tetrazoles / administration & dosage*
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Tetrazoles; N7Z035406B/cilostazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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