| Cilostazol reduces target lesion revascularization after percutaneous transluminal angioplasty in the femoropopliteal artery. | |
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MedLine Citation:
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PMID: 16195627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although percutaneous transluminal angioplasty (PTA) is being widely used for the treatment of stenosis of peripheral arteries, the high in-stent restenosis rate (50-60%) in the femoropopliteal artery still remains an unsolved issue. Cilostazol is a unique antiplatelet drug that has vasodilatory effects and inhibits smooth muscle cell proliferation. METHODS AND RESULTS: A total of 141 consecutive patients scheduled for PTA in the femoropopliteal artery between September 1999 and April 2004 were retrospectively analyzed for the use of cilostazol. Target lesion revascularization (TLR) was defined as repeated PTA in patients who had a recurrence of symptoms with diameter stenosis >50% by angiography. Patient and lesion characteristics were similar between the cilostazol (+) and cilostazol (-) groups. Use of other medications was similar between the groups, except for ticlopidine, which was more frequently used in the cilostazol (-) than in the cilostazol (+) group (15% vs 61%, p<0.01). TLR was significantly reduced in the cilostazol (+) group (12% [8/68] vs 32% [23/73], p<0.01). CONCLUSIONS: Although this study was retrospective and nonrandomized, the results suggest that cilostazol reduces TLR after PTA in the femoropopliteal artery. |
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Authors:
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Osamu Iida; Shinsuke Nanto; Masaaki Uematsu; Takakazu Morozumi; Jun-Ichi Kotani; Masaki Awata; Toshinari Onishi; Noriaki Ito; Fusako Oshima; Hitoshi Minamiguchi; Masafumi Kitakaze; Seiki Nagata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 69 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-30 Completed Date: 2005-12-09 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1256-9 Citation Subset: IM |
Affiliation:
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Kansai Rosai Hospital, Amagasaki, Japan. osa-iida@nifty.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon* / methods Cell Proliferation / drug effects Female Femoral Artery* / surgery Graft Occlusion, Vascular / drug therapy*, metabolism Humans Male Myocytes, Smooth Muscle / metabolism Platelet Aggregation Inhibitors / administration & dosage* Stents* Tetrazoles / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Tetrazoles; N7Z035406B/cilostazol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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