| Ciliary blood flow and aqueous humor production. | |
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MedLine Citation:
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PMID: 20801226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aqueous humor production is a metabolically active process sustained by the delivery of oxygen and nutrients and removal of metabolic waste by the ciliary circulation. This article describes our investigations into the relationship between ciliary blood flow and aqueous humor production. The results presented indicate that there is a dynamic relationship between ciliary blood flow and aqueous humor production, with production being blood flow independent above a critical level of perfusion, and blood flow dependent below it. The results also show that the plateau portion of the relationship shifts up or down depending on the level of secretory stimulation or inhibition, and that oxygen is one critical factor provided by ciliary blood flow. Also presented is a theoretical model of ocular hydrodynamics incorporating these new findings. |
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Authors:
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J W Kiel; M Hollingsworth; R Rao; M Chen; H A Reitsamer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-27 |
Journal Detail:
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Title: Progress in retinal and eye research Volume: 30 ISSN: 1873-1635 ISO Abbreviation: Prog Retin Eye Res Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-04-25 Revised Date: 2012-02-10 |
Medline Journal Info:
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Nlm Unique ID: 9431859 Medline TA: Prog Retin Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 1-17 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. kiel@uthscsa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Aqueous Humor / secretion* Ciliary Body / anatomy & histology, blood supply* Computer Simulation Endothelium, Corneal / anatomy & histology, physiology Humans Hydrodynamics Intraocular Pressure / physiology Models, Biological Oxygen / metabolism Regional Blood Flow / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY09702/EY/NEI NIH HHS; R01 EY009702-15/EY/NEI NIH HHS; R01 EY009702-17/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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