Document Detail


Cilazapril treatment depresses ventricular function in spontaneously hypertensive rats.
MedLine Citation:
PMID:  7977837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to characterize the effect of chronic treatment with an angiotensin-converting enzyme (ACE) inhibitor on left ventricular function in spontaneously hypertensive rats (SHR). Cilazapril (5 mg/kg) was administered in the drinking water continuously for 11 wk, beginning at 4 wk of age. Systolic arterial pressure (SAP) was monitored weekly. At the end of the 11-wk period, left ventricular function was quantified using the perfused working heart preparation. Cilazapril exerted a rapid, complete, and persistent antihypertensive effect in the SHR in vivo but had no effect on SAP in the normotensive Sprague-Dawley (S-D) group. Nevertheless, the drug reduced left ventricular weight to the same extent in both strains. Function of untreated SHR hearts was not different from that of the untreated S-D hearts. Cilazapril treatment depressed heart performance (28-35%) in SHR but had no effect in the S-D group. The decline in pump performance in SHR hearts was associated with diminished tension development and velocity of shortening of papillary muscles. These results demonstrate that an ACE inhibitor, administered to young SHR, produces a reduction in left ventricular contractile function, which may be due to a decline in muscle contractility and which cannot be explained exclusively by the reduction in left ventricular mass.
Authors:
M E Christe; A A Perretta; P Li; J M Capasso; P Anversa; R L Rodgers
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2050-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, University of Rhode Island, Kingston 02881.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Blood Pressure / drug effects*
Body Weight / drug effects
Cilazapril / pharmacology*
Heart / anatomy & histology,  drug effects,  physiopathology
Heart Ventricles
Hypertension / drug therapy,  physiopathology*
Male
Myocardial Contraction / drug effects
Organ Size / drug effects
Papillary Muscles / drug effects,  physiology,  physiopathology
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Stress, Mechanical
Ventricular Function, Left / drug effects*
Grant Support
ID/Acronym/Agency:
HL-38132/HL/NHLBI NIH HHS; HL-39902/HL/NHLBI NIH HHS; HL-40561/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
92077-78-6/Cilazapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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