Document Detail


Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.
MedLine Citation:
PMID:  11762709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the effects of hyperthyroidism on cardiac structural changes and postischemic myocardial function, and also studied how an angiotensin-converting enzyme (ACE) inhibitor, cilazapril, can alter these changes. Hyperthyroidism was induced by daily intraperitoneal injection of thyroxine (T4) (600 microg/kg) with or without cilazapril (10 mg/kg per day, orally), and control rats were given by vehicle. After 2 weeks of treatment, T4-treated rats showed increases in blood pressure and heart weight to body weight ratio (HW:BW). Cilazapril decreased blood pressure to control values and reduced HW:BW. In the isolated working heart preparation, T4-treated rats showed a poor postischemic recovery of left ventricular pressure-rate product (14% of baseline at 30 minutes of reperfusion vs. vehicle 85%) and cardiac work (6% vs. 71%). Cilazapril recovered both values to 49% and 43%. Propranolol (500 mg/L in drinking water) decreased blood pressure to the same extent as cilazapril in hyperthyroid rats, but changed neither HW:BW nor the postischemic myocardial dysfunction. Percent recovery of cardiac work was inversely well correlated with HW:BW (R2 = 0.998, p < 0.001). Results indicate that T4-induced cardiac hypertrophy enhances postischemic cardiac dysfunction. Results also indicate renin-angiotensin system (RAS), but not sympathetic nerve activation, is involved in cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.
Authors:
T Asahi; M Shimabukuro; Y Oshiro; H Yoshida; N Takasu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  11     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1009-15     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Faculty of Medicine, University of The Ryukyus, Nishihara, Okinawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Animals
Cardiomegaly / pathology,  physiopathology,  prevention & control*
Cell Size
Cilazapril / therapeutic use*
Coronary Circulation / drug effects
Hemodynamics / drug effects
Hyperthyroidism / pathology,  physiopathology,  prevention & control*
Hypertrophy, Left Ventricular / pathology
Male
Myocardial Ischemia / pathology,  physiopathology,  prevention & control*
Myocardium / metabolism,  pathology
Organ Size / drug effects
Oxygen Consumption / drug effects
Propranolol / therapeutic use
Rats
Rats, Sprague-Dawley
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 525-66-6/Propranolol; 6893-02-3/Triiodothyronine; 92077-78-6/Cilazapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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