Document Detail

Cilazapril and early atherosclerotic changes after balloon injury of porcine carotid arteries.
MedLine Citation:
PMID:  1532544     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cilazapril, a converting enzyme inhibitor, has been shown to significantly decrease the extent of intimal smooth muscle cell proliferation after arterial injury in a normotensive rat model. METHODS AND RESULTS: To assess the influence of cilazapril on myofibrotic changes after balloon injury, control (n = 7) or cilazapril-treated (n = 9) (20 mg/kg b.i.d.) normal 3-month-old pigs underwent dilatation angioplasty of the right, and deendothelialization of the left common carotid artery. Carotid arteries isolated at 4 weeks were examined morphometrically with a computerized digitizer after in situ glutaraldehyde fixation. Both in the deendothelialized and dilated arteries, the surface area in square millimeters of the neointima and media were similar in the treated and control animals; therefore, the ratio of neointima to media was again not different. The neointimal changes included a combination of proliferative changes as well as organization of mural thrombus and were equally well distributed in the two groups of animals. At the time that the animals were killed, blood pressure (38.2 +/- 2.1 versus 56.8 +/- 4.8 mm Hg, p = 0.003) and plasma angiotensin converting enzyme activity (5.6 +/- 4.1 versus 182.3 +/- 70.4, p = 0.02) were lower in treated than in control pigs, but aortic media thrombogenicity (as assessed in an ex vivo perfusion flow chamber) and serum lipids were not different between groups. CONCLUSIONS: In pigs, cilazapril did not alter the development of myofibrotic changes after mild or severe balloon injury despite plasma angiotensin converting enzyme activity inhibition.
J Y Lam; L Lacoste; M G Bourassa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  85     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-06     Completed Date:  1992-05-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1542-7     Citation Subset:  AIM; IM    
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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MeSH Terms
Angioplasty, Balloon / adverse effects
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Carotid Artery Injuries*
Carotid Stenosis / etiology,  pathology,  prevention & control*
Intracranial Arteriosclerosis / etiology,  pathology,  prevention & control*
Muscle, Smooth, Vascular / drug effects,  injuries
Pyridazines / therapeutic use*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Pyridazines; 92077-78-6/Cilazapril
Comment In:
Circulation. 1992 Apr;85(4):1630-1   [PMID:  1532546 ]

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