Document Detail

Cigarette smoking and the risk of diabetes in women.
MedLine Citation:
PMID:  8427325     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Noninsulin-dependent diabetes mellitus, a major risk factor for cardiovascular disease, is prevalent in more than 12 million Americans. A voluminous amount of data demonstrates that cigarette smoking is an important cause of cancer and coronary heart disease. However, the association between cigarette smoking and the risk of diabetes is virtually unexplored, especially in women. METHODS: We examined the association between smoking and the incidence of noninsulin-dependent diabetes mellitus among 114,247 female nurses who were free of diabetes, cardiovascular disease, and cancer in 1976. We collected exposure information and disease status prospectively for 12 years from biennially self-administered questionnaires. RESULTS: Current smokers had an increased risk of diabetes, and we observed a significant dose-response trend for higher risk among heavier smokers. During 1,277,589 person-years of follow-up, 2333 women were clinically diagnosed with diabetes. The relative risk of diabetes, adjusted for obesity and other risk factors, was 1.42 among women who smoked 25 or more cigarettes per day compared with nonsmokers. CONCLUSIONS: These data suggest that cigarette smoking may be an independent, modifiable risk factor for noninsulin-dependent diabetes mellitus.
E B Rimm; J E Manson; M J Stampfer; G A Colditz; W C Willett; B Rosner; C H Hennekens; F E Speizer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of public health     Volume:  83     ISSN:  0090-0036     ISO Abbreviation:  Am J Public Health     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-04     Completed Date:  1993-03-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-4     Citation Subset:  AIM; IM    
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
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MeSH Terms
Diabetes Mellitus, Type 2 / epidemiology,  etiology*
Dose-Response Relationship, Drug
Middle Aged
Prospective Studies
Risk Factors
Smoking / adverse effects*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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