Document Detail


Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.
MedLine Citation:
PMID:  17328944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cigarette smoking is a major risk factor for acute coronary thrombosis. Bradykinin (BK) can induce the release of tissue plasminogen activator (tPA) from the coronary vasculature. The purpose of this study was to investigate whether smoking reduces BK-stimulated tPA release in human coronary circulation. MATERIALS AND METHODS: We examined two groups: 20 current smokers and 19 nonsmokers. By cardiac catheterization, graded doses of BK (0.2, 0.6 and 2.0 microg/min) and papaverine (PA) (12 mg) were administered into the coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. Blood samples from the aorta (Ao) and coronary sinus (CS) were assayed. RESULTS: BK increased both coronary artery diameter (CD) and CBF to a similar extent in the two groups. The net coronary tPA release was dose-dependently increased by BK in the two groups, but the degree of this increase in current smokers was significantly lower than that in nonsmokers. BK did not change plasminogen activator inhibitor type 1 (PAI 1) levels in either group. PA did not alter either tPA or PAI-1 levels in either group. CONCLUSIONS: These results suggest that cigarette smoking deteriorates coronary fibrolytic activity, independent of changes in CBF. These findings can at least partly explain the higher risk of coronary thrombosis in smokers.
Authors:
Hiroyuki Takashima; Tetsuya Matsumoto; Ichiro Nakae; Tetsunobu Yamane; Minoru Horie
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2007-02-27
Journal Detail:
Title:  Thrombosis research     Volume:  120     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-6     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan.
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MeSH Terms
Descriptor/Qualifier:
Bradykinin / administration & dosage*,  metabolism
Coronary Angiography
Coronary Circulation / drug effects,  physiology*
Coronary Thrombosis / blood*,  epidemiology
Female
Fibrinogen / drug effects,  physiology
Heart Catheterization
Humans
Male
Middle Aged
Papaverine / administration & dosage
Risk Factors
Smoking / adverse effects*,  epidemiology
Tissue Plasminogen Activator / blood*
Vasodilator Agents / administration & dosage*,  metabolism
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine; 58-82-2/Bradykinin; 9001-32-5/Fibrinogen; EC 3.4.21.68/Tissue Plasminogen Activator

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