Document Detail

Cigarette smoking affects uterine receptiveness.
MedLine Citation:
PMID:  17095517     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cigarette smoking has long been known to have an effect on female fertility. The existence of an ovarian factor is clear when one considers that the mean age of the menopause is lower and IVF cycle outcome is worse in heavy smokers. The hypothesis of a concomitant uterine effect is raised by indirect evidence from in vitro and in vivo studies, but as yet, no direct evidence has been gained to confirm its existence. In this work, we analyse the association between smoking habit in oocyte recipients and cycle outcome. METHODS: We have retrospectively analysed the outcome of all oocyte donation cycles performed in our clinic from January 2002 to June 2005 from which there was available information regarding patient current smoking status. Husband and donor smoking status were controlled variables, as well as donor and recipient age, patient body mass index, embryo number and quality and duration of endometrial priming. RESULTS: Pregnancy rate (PR) in non-heavy smokers (0-10 cigarettes/day) was significantly higher than in heavy smokers (>10 cigarettes/day) (52.2 versus 34.1%, respectively). Interestingly, multiple PR was significantly higher in heavy smokers (60 versus 31%). CONCLUSION: Tobacco consumption determines reduced uterine receptiveness and an increased risk of multiple pregnancies. This last issue remains to be clarified.
S R Soares; C Simon; J Remohí; A Pellicer
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Publication Detail:
Type:  Journal Article     Date:  2006-11-09
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  22     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-11     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  543-7     Citation Subset:  IM    
IVI-Lisboa, Infante Dom Henrique, Lisbon, Portugal.
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MeSH Terms
Abortion, Spontaneous / epidemiology
Oocyte Donation
Pregnancy Rate*
Pregnancy, Multiple
Reproductive Techniques, Assisted*
Retrospective Studies
Smoking / adverse effects*
Spain / epidemiology
Uterus / physiology*

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