| Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation. | |
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MedLine Citation:
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PMID: 19237681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown recently that repetition of ischemic preconditioning stimulus augments endothelium-dependent vasodilation in forearm circulation of healthy subjects through increases in NO production and the number of circulating progenitor cells under a local condition. The purpose of this study was to evaluate the "late" effect of ischemic preconditioning on endothelial function in smokers. Ischemic preconditioning was induced by upper-limb ischemia 6 times a day for 1 month. We evaluated forearm blood flow responses to acetylcholine and sodium nitroprusside before and after ischemic preconditioning stimulus in 15 male smokers (27+/-7 years) and 15 male nonsmokers (26+/-5 years). Forearm blood flow was measured by using a strain-gauge plethysmography. The ischemic preconditioning stimulus resulted in significant increases in the circulating level of circulating progenitor cells from 1029+/-261 to 1232+/-341 mL (P=0.02), cell migration response to vascular endothelial growth factor from 38+/-16 to 52+/-17 per high-power field (P=0.02), and forearm blood flow response to acetylcholine from 25.1+/-5.2 to 32.4+/-6.6 mL/min per 100 mL of tissue (P=0.002) in nonsmokers, but these did not change in the smoker group. The forearm blood flow responses to sodium nitroprusside before and after the ischemic preconditioning stimulus were similar. Intra-arterial infusion of N(G)-monomethyl-l-arginine, an NO synthase inhibitor, completely eliminated the ischemic preconditioning stimulus-induced augmentation of forearm blood flow responses to acetylcholine in nonsmokers. These findings suggest that repetition of ischemic preconditioning stimulus may be a simple, safe, and feasible therapeutic technique for endothelial protection of peripheral vessels. However, smoking abolishes ischemic preconditioning stimulus-induced augmentation of endothelium-dependent vasodilation. |
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Authors:
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Shuji Nakamura; Masashi Kimura; Chikara Goto; Kensuke Noma; Masao Yoshizumi; Kazuaki Chayama; Yasuki Kihara; Yukihito Higashi |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-23 |
Journal Detail:
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Title: Hypertension Volume: 53 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 674-81 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Mimami-ku, Hiroshima 734-8551, Japan. yhigashi@hiroshima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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administration & dosage Adult Endothelium, Vascular / drug effects, physiology* Enzyme Inhibitors / administration & dosage Forearm / blood supply Hematopoietic Stem Cells / cytology, physiology Humans Infusions, Intra-Arterial Ischemia / physiopathology* Ischemic Preconditioning* Male Nitroarginine / administration & dosage Nitroprusside / administration & dosage Plethysmography Smoking / adverse effects* Vascular Endothelial Growth Factor A / blood Vasodilation / drug effects, physiology* Vasodilator Agents / administration & dosage Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 2149-70-4/Nitroarginine; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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