| Cigarette Smoking, Coffee Drinking, and Ingestion of Charcoal-broiled Beef as Potential Modifiers of Drug Therapy and Confounders of Clinical Trials. | |
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MedLine Citation:
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PMID: 22514335 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A pathway of research is described leading from the finding of an inhibitory effect of 3-methylcholanthrene on the carcinogenicity of an aminoazo dye, to the induction of drug-metabolizing enzymes by 3-methylcholanthrene, benzo[a]pyrene and other polycyclic aromatic hydrocarbons, to the demonstration of enhanced drug metabolism in cigarette smokers, coffee drinkers and in people eating charcoal-broiled beef. The results of these studies indicate that cigarette smoking, coffee drinking and the ingestion of charcoal-broiled beef (all result in exposure to polycyclic aromatic hydrocarbons) can influence the dosing regimen needed for proper drug therapy and are potential confounders of clinical trials with drugs metabolized by polycyclic aromatic hydrocarbon-inducible enzymes. |
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Authors:
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Allan H Conney; Marcus M Reidenberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-18 |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: - ISSN: 1521-0103 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Rutgers, The State University of New Jersey; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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