| Cidea promotes hepatic steatosis by sensing dietary fatty acids. | |
| | |
MedLine Citation:
|
PMID: 22278400 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
High levels of dietary saturated fat have been closely associated with the development of hepatic steatosis, but the factors that mediate this process remain elusive. Here, we observed that the level of Cidea expression was highly correlated with the severity of hepatic steatosis in humans. Overexpression of Cidea in mouse liver resulted in increased hepatic lipid accumulation and the formation of large lipid droplets (LDs). In contrast, mice with a Cidea deficiency had decreased lipid accumulation and alleviated hepatic steatosis when they received an HFD feeding or in ob/ob mice. Furthermore, the knockdown of Cidea in the livers of ob/ob mice resulted in significantly reduced hepatic lipid accumulation and smaller LDs. Importantly, we observed that Cidea expression in hepatocytes was specifically induced by saturated fatty acids, and such induction was reduced when SREBP1c was knocked down. In contrast, the overexpression of SREBP1c restored the saturated fatty acid-induced expression of Cidea. In addition, we observed that the stability of Cidea protein in hepatocytes increased significantly in response to treatment with fatty acids. CONCLUSION: Cidea plays critical roles in promoting hepatic lipid accumulation and in the development of hepatic steatosis by acting as a sensor that responds to diets that contain fatty acids. (HEPATOLOGY 2012.). |
| | |
Authors:
|
Linkang Zhou; Li Xu; Jing Ye; De Li; Wenshan Wang; Xuanhe Li; Lizhen Wu; Hui Wang; Feifei Guan; Peng Li |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: - ISSN: 1527-3350 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
|
Tsinghua University- Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pre-internship Nigerian medical graduates lack basic musculoskeletal competency.
Next Document: Visible to near-infrared light harvesting in Ag(2)S nanoparticles/ZnO nanowire array photoanodes.